Specialty Pulmonary and Critical Care
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Featured
Discovering the Pathways That Lead to Allergic Asthma
Jehan Alladina, MD, and colleagues of the Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital, are using an innovative in vivo research method to study allergic asthma pathogenesis.
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T Cells With Known Specificity Used to Determine the Treg Response in Lung Injury
Daniel S. Shin, MD, PhD, James J. Moon, PhD, and colleagues have discovered that in response to acute lung injury, self-antigen-specific CD4+ T cells have a strong propensity to polarize toward a regulatory function that limits further damage and the possibility of autoimmunity.
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Targeted Nanoparticles Permit Cell-specific Drug Delivery in Pulmonary Fibrosis
Massachusetts General Hospital researchers developed nanoparticles that target myofibroblasts in fibrotic lung tissue, using a peptide recognized by the angiotensin II type 2 receptor. Inhibiting the Rho/MRTF/SRF pathway was therapeutic in a mouse model of pulmonary fibrosis, with minimal off-target toxicity.
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Factors Identified That Influence Lymph Node Harvest During Esophagectomy by Thoracic Surgeons
Massachusetts General Hospital researchers found that during esophagectomy for primary esophageal cancer, specialized thoracic surgeons harvest a median of 16 lymph nodes, slightly exceeding the standard of the National Comprehensive Cancer Network, and minimally invasive surgery is linked to higher yields.
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Lymph Node Harvest, Upstaging After Lobectomy for NSCLC Linked to Hospital Volume
Henning A. Gaissert, MD, and colleagues reviewed a Society of Thoracic Surgeons database for 2012 to 2019 and report increased likelihood of nodal upstaging at hospitals that perform a low annual volume of lobectomies for non–small-cell lung cancer—but 25% of high-volume centers failed to harvest ≥10 nodes on average.
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Pulmonary Function at Time of Lung Cancer Diagnosis Has Prognostic Value
David C. Christiani, MD, MPH, and colleagues found in a large cohort of patients newly diagnosed with non–small-cell lung cancer that poorer spirometry results were linearly associated with worse survival, even after accounting for age, sex, smoking status, tumor histology, cancer stage, and types of treatment.
Pulmonary and Critical Care Medicine Contributors
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Alexandra K. Wong, MD
Physician, Pulmonary and Critical Care Medicine, Massachusetts General Hospital
Recent Article
Studies Work to Improve Pulmonary Hypertension and HHT Care -
Alison S. Witkin, MD
Associate Director, Pulmonary Hypertension and Thromboendarterectomy Program, Massachusetts General Hospital
Recent Article
Medical Grand Rounds: Multidisciplinary Cases From Pregnancy to Menopause
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Benjamin David Medoff, MD
Principal Investigator, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Associate Professor of Medicine, Harvard Medical School
Recent Article
Targeted Nanoparticles Permit Cell-specific Drug Delivery in Pulmonary Fibrosis
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Charles Corey Hardin, MD, PhD
Physician, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Assistant Professor of Medicine, Harvard Medical School, Physician Investigator, Pulmonary, Mass General Research Institute
Recent Article
Persistent Dyspnea After COVID-19 May Have Another Cause
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David Christopher Christiani, MD, MPH
Director of the Christiani Lab, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Staff Physician, Pulmonary and Critical Care Unit, Professor of Medicine, Harvard Medical School
Recent Article
Pulmonary Function at Time of Lung Cancer Diagnosis Has Prognostic Value
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Erik Folch, MD, MSc
Chief, Complex Chest Disease Center, Co-Director, Interventional Pulmonology, Assistant Professor of Medicine, Massachusetts General Hospital
Recent Article
Promising Experience With Robotic-assisted Bronchoscopy for Biopsy of Small Peripheral Pulmonary Nodules -
George A. Alba, MD
Pulmonary and Critical Care Physician, Instructor of Medicine at Harvard Medical School
Recent Article
Mass General Pulmonologist Explores Role of NEDD9 in ARDS
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Jehan W. Alladina, MD
Physician, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Instructor in Medicine, Harvard Medical School
Recent Article
Research Reveals Novel Molecular Mechanisms Specific to Allergic Asthma
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Laura N. Brenner, MD
Pulmonologist, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital
Recent Article
Cats and Bats and Pangolins: The Origin of Sars-Cov-2 -
Lorenzo Berra, MD
Medical Director, Respiratory Care, Massachusetts General Hospital
Recent Article
Inhaled Nitric Oxide Improves Oxygenation in Pregnant Patients With COVID-19 Pneumonia
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Melissa J. Suter, PhD
Associate Professor in Medicine, Harvard Medical School, Assistant in Biomedical Engineering, Massachusetts General Hospital
Recent Article
Maximizing Clinical Utility of Pulmonary Optical Imaging -
Raghu Chivukula, MD, PhD
Physician-Scientist, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital
Recent Article
Review: Evidence-Based Management of the Critically Ill Adult with COVID-19
Pulmonary and Critical Care Medicine
The Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital provides comprehensive care for the full range of respiratory conditions and diseases.