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Featured
Pathways Case Record: Nocturnal Hypothermia and HIV in a 53-Year-Old Woman
The Pathways Consult Service at Massachusetts General Hospital investigates the case of a 53-year-old female patient with HIV who presented with cyclical hypothermic episodes. They hypothesized that an autoimmune process related to immune reconstitution on HIV treatment led to the dysfunction of temperature regulation.
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Featured
Pathways Case Record: An Epigenetic Memory of Infection in the Lung
The Pathways Consult Service at Massachusetts General Hospital investigated the case of a 75-year-old woman who was admitted for dyspnea and cachexia stemming from severe and progressive allergic bronchopulmonary aspergillosis and bronchiectasis.
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Featured
Pathways Case Record: Severe Encephalitis, Mitochondrial Dysfunction in a 28-Year-Old Patient
The Pathways Consult Service at Massachusetts General Hospital took on the case of a patient with severe encephalitis. They sought to find whether the development of lactic acidosis on linezolid therapy could provide insight into the development of his condition.
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Pathways Case Record: Familial Dilated Cardiomyopathy
Genetic testing of a woman with heart failure due to newly diagnosed dilated cardiomyopathy (DCM) revealed a likely pathogenic heterozygous mutation in the TTN gene. The Pathways Consult Service investigated the likely impact of TTN mutation on cardiomyocyte function and its potential causative role in DCM.
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Pathways Case Record: A Patient With Renal Failure Found to Have Nephrotic Syndrome With Histopathological Findings of Podocyte Effacement
A 63-year-old man with renal failure underwent a kidney biopsy for presumed nephrotic syndrome, which revealed severe podocyte injury. The Pathways Service was consulted to elucidate the current mechanism of injury to the patient's podocytes and the pathophysiologic underpinnings of his nephrotic syndrome.
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Pathways Case Record: Novel Insights Into Clinical Severity in Sickle Cell Disease
A 28-year-old woman with sickle cell disease (SCD) was hospitalized with fever, productive cough, and joint pain. She was transferred to Massachusetts General Hospital due to concern for acute respiratory failure and a high white blood cell count. The Pathways Service focused on the course of SCD in this patient.
Pathways Consult Service
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Jay Vyas, MD, PhD
Program Director, Internal Medicine Residency Program, Principal Investigator, Vyas Laboratory, Massachusetts General Hospital, Associate Professor of Medicine, Harvard Medical School
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Rebecca Ward, PhD
Medical Writer, Vyas Laboratory, Massachusetts General Hospital