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Featured
Pathways Case Record: Nocturnal Hypothermia and HIV in a 53-Year-Old Woman
The Pathways Consult Service at Massachusetts General Hospital investigates the case of a 53-year-old female patient with HIV who presented with cyclical hypothermic episodes. They hypothesized that an autoimmune process related to immune reconstitution on HIV treatment led to the dysfunction of temperature regulation.
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Featured
Pathways Case Record: An Epigenetic Memory of Infection in the Lung
The Pathways Consult Service at Massachusetts General Hospital investigated the case of a 75-year-old woman who was admitted for dyspnea and cachexia stemming from severe and progressive allergic bronchopulmonary aspergillosis and bronchiectasis.
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Featured
Pathways Case Record: Severe Encephalitis, Mitochondrial Dysfunction in a 28-Year-Old Patient
The Pathways Consult Service at Massachusetts General Hospital took on the case of a patient with severe encephalitis. They sought to find whether the development of lactic acidosis on linezolid therapy could provide insight into the development of his condition.
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Pathways Case Record: Novel Insights Into Clinical Severity in Sickle Cell Disease
A 28-year-old woman with sickle cell disease (SCD) was hospitalized with fever, productive cough, and joint pain. She was transferred to Massachusetts General Hospital due to concern for acute respiratory failure and a high white blood cell count. The Pathways Service focused on the course of SCD in this patient.
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Pathways Case Record: A Case of Neutropenia in a Young Adult
An 18-year-old woman was admitted to Massachusetts General Hospital for neutropenia (low neutrophil counts) and oral ulcers. The Pathways Consult Service investigated and focused on the etiology of the patient's neutropenia and what therapeutic options are available.
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Pathways Case Record: Investigating Paraneoplastic Autoimmunity: A Case of Dermatomyositis in a Patient With Rectal Adenocarcinoma
A 55-year-old woman with a history of resected rectal adenocarcinoma was admitted for progressive proximal muscle weakness and rash; she was diagnosed with inflammatory myositis overlap syndrome. The Pathways Service was consulted and investigated the potential association between autoimmune diseases and malignancies.
Pathways Consult Service
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Jay Vyas, MD, PhD
Program Director, Internal Medicine Residency Program, Principal Investigator, Vyas Laboratory, Massachusetts General Hospital, Associate Professor of Medicine, Harvard Medical School
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Pathways Case Records Team,
Recent Article
Pathways Case Record: Novel Insights Into Clinical Severity in Sickle Cell Disease -
Rebecca Ward, PhD
Medical Writer, Vyas Laboratory, Massachusetts General Hospital
Pathways Consult Service
Pathways Consult Service at Massachusetts General Hospital is discovering insights into the causes of disease through the close investigation of a single patient.