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Featured
Pathways Case Record: Nocturnal Hypothermia and HIV in a 53-Year-Old Woman
The Pathways Consult Service at Massachusetts General Hospital investigates the case of a 53-year-old female patient with HIV who presented with cyclical hypothermic episodes. They hypothesized that an autoimmune process related to immune reconstitution on HIV treatment led to the dysfunction of temperature regulation.
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Featured
Pathways Case Record: An Epigenetic Memory of Infection in the Lung
The Pathways Consult Service at Massachusetts General Hospital investigated the case of a 75-year-old woman who was admitted for dyspnea and cachexia stemming from severe and progressive allergic bronchopulmonary aspergillosis and bronchiectasis.
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Featured
Pathways Case Record: Severe Encephalitis, Mitochondrial Dysfunction in a 28-Year-Old Patient
The Pathways Consult Service at Massachusetts General Hospital took on the case of a patient with severe encephalitis. They sought to find whether the development of lactic acidosis on linezolid therapy could provide insight into the development of his condition.
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Pathways Case Record: Investigating Paraneoplastic Autoimmunity: A Case of Dermatomyositis in a Patient With Rectal Adenocarcinoma
A 55-year-old woman with a history of resected rectal adenocarcinoma was admitted for progressive proximal muscle weakness and rash; she was diagnosed with inflammatory myositis overlap syndrome. The Pathways Service was consulted and investigated the potential association between autoimmune diseases and malignancies.
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Pathways Case Record: A Patient With Cirrhosis and Small Bowel Edema
A 39-year-old man presented with an acute episode of severe epigastric pain, and initial evaluation revealed extensive small bowel edema and C1 esterase inhibitor (C1-INH) deficiency. The Pathways Service team was consulted to investigate the pathophysiologic mechanism for his dramatic small bowel edema.
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Pathways Case Record: Small Fiber Neuropathy and Recurrent GI Infections
A 24-year-old woman with postural orthostatic tachycardia syndrome, small fiber neuropathy, and impaired gastrointestinal (GI) motility presented with recurrent blood infections and bacteria in her gut. The Pathways Team investigated a relationship between the patient's neuropathy and recurrent GI bacterial infections.
Pathways Consult Service
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Jay Vyas, MD, PhD
Program Director, Internal Medicine Residency Program, Principal Investigator, Vyas Laboratory, Massachusetts General Hospital, Associate Professor of Medicine, Harvard Medical School
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Pathways Case Records Team,
Recent Article
Pathways Case Record: Investigating Paraneoplastic Autoimmunity: A Case of Dermatomyositis in a Patient With Rectal Adenocarcinoma -
Rebecca Ward, PhD
Medical Writer, Vyas Laboratory, Massachusetts General Hospital
Pathways Consult Service
Pathways Consult Service at Massachusetts General Hospital is discovering insights into the causes of disease through the close investigation of a single patient.