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Featured
Innovations in ALS Clinical Trials
Merit Cudkowicz, MD, MSc, chief of Neurology at Massachusetts General Hospital, discusses innovations in ALS clinical trials since she started in the field in 1994.
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Featured
Advancements in the Treatment of Neurodegenerative Disease
In this video, Ghazaleh Sadri-Vakili, PhD, director of the NeuroEpigenetics Laboratory and the MassGeneral Institute of Neurodegenerative Disease, discusses her genetic research, specifically concerning neurodegenerative diseases like ALS and X-linked dystonia parkinsonism.
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Featured
Identifying New Potential Therapeutic Targets for ALS FTD
Transcripts of repeat expansions in the C90RF72 gene undergo a repeat-associated non-AUG (RAN) translation pathway that generates multiple aberrant proteins. Researchers at Mass General Hospital identified new potential therapeutic targets for ALS FTD.
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Tofersen for ALS Clears Phase 1/2 Trial, Now in Phase 3
Tofersen, an investigational therapy for amyotrophic lateral sclerosis caused by SOD1 mutations, was safe and generally well tolerated over 12 weeks and lowered SOD1 protein levels in cerebrospinal fluid.
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High-Dose Tamoxifen "Wins" Selection Trial in ALS
In a selection trial—a randomized trial in which multiple experimental treatments were compared simultaneously—tamoxifen 80 mg/day was numerically superior to tamoxifen 40 mg/day and creatine 30 g/day on the primary endpoint of functional decline.
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Mortality from Neurodegenerative Disease Not a Concern in Major League Baseball
All-cause mortality and mortality from neurodegenerative disease are no higher among Major League Baseball than the general population, but playing professional baseball seems to increase mortality from certain cancers.
ALS contributors
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Clotilde Lagier-Torurenne, MD, PhD
Assistant Professor of Neurology, Harvard Medical School, Assistant in Neuroscience, Massachusetts General Hospital
Recent Article
Researchers Identify a New Therapeutic Target for TDP-43-mediated Neurodegenerative Diseases
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Ghazaleh Sadri-Vakili, MS, PhD
Assistant in Neuroscience, Massachusetts General Hospital, Assistant Professor of Neurology, Harvard Medical School
Recent Article
Cromolyn Sodium Provides Neuroprotection in Animal Model of ALS
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James D. Berry, MD, MPH
Co-director, Multidisciplinary Amyotrophic Lateral Sclerosis (ALS) Clinic
Recent Article
Infusions of Regulatory T Cells Slowed ALS Progression in First-in-Humans Trial
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Merit Ester Cudkowicz, MD, MSc
Chief, Neurology Service, Director of the Sean M. Healey & AMG Center for ALS at Mass General, Director of Neurological Clinical Research Institute and the Jilieane Dorn Professor of Neurology, Harvard Medical School
Recent Article
Tofersen for ALS Clears Phase 1/2 Trial, Now in Phase 3
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Nazem Atassi, MD
Associate Director, Neurological Clinical Research Institute (NCRI), Mass General Hospital, Associate Professor of Neurology, Harvard Medical School
Recent Article
High-Dose Tamoxifen "Wins" Selection Trial in ALS
Neuroscience Care at Mass General
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