Clotilde trained as both a medical geneticist and a neuroscientist, earning her MD at the Medical School of Strasbourg, France and a PhD from the University Louis Pasteur, Strasbourg. She received further training in Medical Genetics at Columbia University, where her work focused on the identification of new genetic causes of neurological disorders. After a postdoctoral training with Dr. Don Cleveland at the Ludwig Institute for Cancer Research, she became an Assistant Professor at the University of California San Diego until 2015, when she moved to MGH. She received the Alphonse Laveran Prize, the Milton-Safenowitz Postdoctoral Fellowship from the Amyotrophic Lateral Sclerosis Association, the Muscular Dystrophy Association Career Development Award, and the Frick Foundation 2013 Award (conjointly with Dr. Luc Dupuis). In 2014, Clotilde was awarded the 6th International Medicine Paulo Gontijo Award, which recognizes the most promising scientist under the age of 40 working on ALS. Clotilde is an Associate Member of the Broad Institute of MIT and Harvard.