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Featured
Advancements in the Treatment of Neurodegenerative Disease
In this video, Ghazaleh Sadri-Vakili, PhD, director of the NeuroEpigenetics Laboratory and the MassGeneral Institute of Neurodegenerative Disease, discusses her genetic research, specifically concerning neurodegenerative diseases like ALS and X-linked dystonia parkinsonism.
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Featured
Tau PET Imaging May Help Identify People with Pre-symptomatic Alzheimer’s Disease
Brain changes associated with Alzheimer’s disease can now be studied in living people. Mass General researchers imaged cognitively normal people who are destined to develop AD due to a rare genetic mutation. Their goal: to discover how soon brain changes are present before symptoms begin and how soon preventive treatments could be initiated.
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Featured
Identifying New Potential Therapeutic Targets for ALS FTD
Transcripts of repeat expansions in the C90RF72 gene undergo a repeat-associated non-AUG (RAN) translation pathway that generates multiple aberrant proteins. Researchers at Mass General Hospital identified new potential therapeutic targets for ALS FTD.
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Potential New Drug Target for Huntington's Disease Identified
Building on previous research, neuroscientists at Massachusetts General Hospital have demonstrated why compounds targeting the Hippo pathway should be considered for treatment of Huntington's disease.
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Infusions of Regulatory T Cells Slowed ALS Progression in First-in-Humans Trial
A phase 1 trial has demonstrated the safety of autologous infusions of regulatory T cells into patients with ALS, with potential benefit in terms of slowing disease progression.
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Stratification Based on Predicted Survival Could Improve Randomization of ALS Trials
Stratifying ALS clinical trial participants improved randomization of simulated ALS trials compared with traditional methods, which may allow for a reduced sample size needed.
Learn more about the MassGeneral Institute for Neurodegenerative Disease
Neurodegenerative Disease contributors
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Ghazaleh Sadri-Vakili, MS, PhD
Assistant in Neuroscience, Massachusetts General Hospital, Assistant Professor of Neurology, Harvard Medical School
Recent Article
Potential New Drug Target for Huntington's Disease Identified
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Joel A. Salinas, MD, MSc, MBA
Chief, McCance Brain Health Unit
Recent Article
Social Relationships May Influence Stroke and Dementia Risk
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Jonathan Rosand, MD
Co-Director, Henry and Allison McCance Center for Brain Health, Chief, Division of Neurocritical Care and Emergency Neurology, Medical Director, Neuroscience Intensive Care Unit
Recent Article
Genetic Variation and Risk of Stroke
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Keith A. Johnson, MD
Radiologist
Recent Article
Tau PET Imaging May Help Identify People with Pre-symptomatic Alzheimer’s Disease
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Yakeel T. Quiroz-Gaviria, PhD
Co-Director, MGH Multicultural Neuropsychology Program (MUNDOS)
Recent Article
Tau PET Imaging May Help Identify People with Pre-symptomatic Alzheimer’s Disease
Neuroscience Care at Mass General
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