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Featured
Cromolyn Sodium Provides Neuroprotection in Animal Model of ALS
Building on similar research in Alzheimer's disease, researchers at Massachusetts General Hospital demonstrated that treatment with cromolyn sodium delayed disease onset and was neuroprotective in a mouse model of amyotrophic lateral sclerosis by decreasing the inflammatory response.
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Featured
Case of Resistance to Autosomal Dominant Alzheimer's Disease Suggests New Direction for Treatment
A woman with autosomal dominant Alzheimer's disease had very late onset of mild cognitive impairment, apparently because she was homozygous for the APOE3 Christchurch mutation.
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Featured
Patterns of Neural Network Degradation Differ in Alzheimer's Disease and Normal Aging
Functional MRI may someday be able to distinguish the neurodegenerative changes related to early Alzheimer's disease from those of normal aging.
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Tau Pathobiology Differs Among Individuals with Alzheimer's Disease
Researchers at Massachusetts General Hospital observed differences in the kinetics of tau aggregation across brain tissue samples from individuals with sporadic Alzheimer's disease, confirming and extending the concept of patient-specific characteristics of tau in this disease.
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AI Models to Assess Histopathologic Markers of Alzheimer's Disease, Cerebral Amyloid Angiopathy
Valentina Perosa, MD, and Susanne J. van Veluw, PhD, of the Department of Neurology, and colleagues have developed the first convolutional neural networks that can identify and quantify biologically relevant histopathological markers of both Alzheimer's disease and cerebral amyloid angiopathy.
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Novel Target Identified for Treatment of ALS
Tiziana Petrozziello, PhD, and Ghazaleh Sadri-Vakili, PhD, of the Healey Center for ALS, and colleagues are the first to report that alterations in tau phosphorylation underlie mitochondrial dysfunction in amyotrophic lateral sclerosis and an investigational tau degrader might mitigate that dysfunction.
Neurodegenerative Disease Contributors
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Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
The Future of Neurosurgery and Neuroscience at Mass General: Q&A With Bob S. Carter, MD, PhD
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Ghazaleh Sadri-Vakili, MS, PhD
Assistant in Neuroscience, Massachusetts General Hospital, Assistant Professor of Neurology, Harvard Medical School
Recent Article
Novel Target Identified for Treatment of ALS
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Jeffrey S. Schweitzer, MD, PhD
Neurosurgeon
Recent Article
Patient-derived Dopamine Neurons Show Promise in Parkinson's Treatment
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Joel A. Salinas, MD, MSc, MBA
Chief, McCance Brain Health Unit
Recent Article
MicroRNA From Whole Blood May Be Stroke Biomarker, Therapeutic Target
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Jonathan Rosand, MD
Co-Director, Henry and Allison McCance Center for Brain Health, Chief, Division of Neurocritical Care and Emergency Neurology, Medical Director, Neuroscience Intensive Care Unit
Recent Article
Pilot Trial: Resiliency Intervention Feasible for Survivors of Critical Neurologic Illness, Family Caregivers
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Keith A. Johnson, MD
Radiologist
Recent Article
Tau PET Imaging May Help Identify People with Pre-symptomatic Alzheimer’s Disease
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Todd M. Herrington, MD, PhD
Director, Deep Brain Stimulation Program, Massachusetts General Hospital
Recent Article
Patient-derived Dopamine Neurons Show Promise in Parkinson's Treatment
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Yakeel T. Quiroz-Gaviria, PhD
Associate Professor, Harvard Medical School, Director, Familial Dementia Neuroimaging Lab, Director, Multicultural Alzheimer's Prevention Program, Massachusetts General Hospital, Paul B. and Sandra M. Edgerley MGH Research Scholar 2020-2025
Recent Article
Retinal Imaging Detects Biomarkers of Familial Alzheimer's Disease Years Before Symptoms
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.Resource Links
