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Featured
Cromolyn Sodium Provides Neuroprotection in Animal Model of ALS
Building on similar research in Alzheimer's disease, researchers at Massachusetts General Hospital demonstrated that treatment with cromolyn sodium delayed disease onset and was neuroprotective in a mouse model of amyotrophic lateral sclerosis by decreasing the inflammatory response.
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Featured
Case of Resistance to Autosomal Dominant Alzheimer's Disease Suggests New Direction for Treatment
A woman with autosomal dominant Alzheimer's disease had very late onset of mild cognitive impairment, apparently because she was homozygous for the APOE3 Christchurch mutation.
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Featured
Patterns of Neural Network Degradation Differ in Alzheimer's Disease and Normal Aging
Functional MRI may someday be able to distinguish the neurodegenerative changes related to early Alzheimer's disease from those of normal aging.
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Mass General's CTRU Advances Research in Complex Brain Disorders
Massachusetts General Hospital's Clinical and Translational Research Unit (CTRU) supports investigators conducting complex brain disorders research.
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Endoplasmic Reticulum Proteins Regulate Organelle Distribution; Change in Function May Treat Neurologic Disease
Craig Blackstone, MD, PhD, and colleagues discovered interaction between the endoplasmic reticulum (ER) and microtubules modified by ER proteins plays a key role in the positioning of cellular organelles. Changing ER function by "fine-tuning" molecular interactions may have applications in treating neurologic diseases.
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Healey Platform ALS Trial Expected to Expedite U.S. Approval of New Treatments
The Healey Platform ALS Trial, headquartered at Massachusetts General Hospital, launched in July 2020 and is expected to bring new treatments to patients with amyotrophic lateral sclerosis more quickly and at lower cost than randomized, controlled trials of single agents.
Neurodegenerative Disease Contributors
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Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
The Future of Neurosurgery and Neuroscience at Mass General: Q&A With Bob S. Carter, MD, PhD
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Ghazaleh Sadri-Vakili, MS, PhD
Assistant in Neuroscience, Massachusetts General Hospital, Assistant Professor of Neurology, Harvard Medical School
Recent Article
Novel Target Identified for Treatment of ALS
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Jeffrey S. Schweitzer, MD, PhD
Neurosurgeon
Recent Article
Patient-derived Dopamine Neurons Show Promise in Parkinson's Treatment
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Joel A. Salinas, MD, MSc, MBA
Chief, McCance Brain Health Unit
Recent Article
MicroRNA From Whole Blood May Be Stroke Biomarker, Therapeutic Target
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Jonathan Rosand, MD
Co-Director, Henry and Allison McCance Center for Brain Health, Chief, Division of Neurocritical Care and Emergency Neurology, Medical Director, Neuroscience Intensive Care Unit
Recent Article
Pilot Trial: Resiliency Intervention Feasible for Survivors of Critical Neurologic Illness, Family Caregivers
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Keith A. Johnson, MD
Radiologist
Recent Article
Tau PET Imaging May Help Identify People with Pre-symptomatic Alzheimer’s Disease
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Todd M. Herrington, MD, PhD
Director, Deep Brain Stimulation Program, Massachusetts General Hospital
Recent Article
Patient-derived Dopamine Neurons Show Promise in Parkinson's Treatment
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Yakeel T. Quiroz-Gaviria, PhD
Associate Professor, Harvard Medical School, Director, Familial Dementia Neuroimaging Lab, Director, Multicultural Alzheimer's Prevention Program, Massachusetts General Hospital, Paul B. and Sandra M. Edgerley MGH Research Scholar 2020-2025
Recent Article
Early Brain Changes Predict Alzheimer's Disease in Individuals at Genetic Risk
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.