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Featured
Cromolyn Sodium Provides Neuroprotection in Animal Model of ALS
Building on similar research in Alzheimer's disease, researchers at Massachusetts General Hospital demonstrated that treatment with cromolyn sodium delayed disease onset and was neuroprotective in a mouse model of amyotrophic lateral sclerosis by decreasing the inflammatory response.
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Featured
Case of Resistance to Autosomal Dominant Alzheimer's Disease Suggests New Direction for Treatment
A woman with autosomal dominant Alzheimer's disease had very late onset of mild cognitive impairment, apparently because she was homozygous for the APOE3 Christchurch mutation.
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Featured
Patterns of Neural Network Degradation Differ in Alzheimer's Disease and Normal Aging
Functional MRI may someday be able to distinguish the neurodegenerative changes related to early Alzheimer's disease from those of normal aging.
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Hematopoietic Stem-Cell Gene Therapy Restores White Matter Microvascular Function in Cerebral Adrenoleukodystrophy
Arne Lauer, MD, Patricia L. Musolino, MD, PhD, and colleagues found that ABCD1 gene therapy with autologous hematopoietic stem cells halts the progression of cerebral adrenoleukodystrophy at least in part because it improves microvascular circulation of the entire cerebral white matter.
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Novel AAV Capsid, Truncated ChAT Promoter Address Challenges in Intracranial Gene Therapy
Miguel C. Santoscoy, PhD, Casey A. Maguire, PhD, and colleagues have developed an adeno-associated virus capsid that transduces a broad area of the striatum upon intracranial injection in mice and a truncated human choline acetyltransferase promoter that allows efficient, selective transduction of cholinergic neurons.
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Pneumatic Dilation for Achalasia Generally Safe in Older Adults
Braden Kuo, MD, and colleagues have demonstrated pneumatic dilation for achalasia is safer, overall, for patients ≥65 years of age than for younger patients, as periprocedural adverse events occurred in 2.6% vs. 10.9% of patients (P=0.017).
Neurodegenerative Disease Contributors
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Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease
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Ghazaleh Sadri-Vakili, MS, PhD
Assistant in Neuroscience, Massachusetts General Hospital, Assistant Professor of Neurology, Harvard Medical School
Recent Article
Novel Target Identified for Treatment of ALS
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Jeffrey S. Schweitzer, MD, PhD
Neurosurgeon, Department of Neurosurgery, Massachusetts General Hospital, Assistant Professor of Neurosurgery, Harvard Medical School
Recent Article
Essential Tremor Treatment Advancements Using MRI-guided Focused Ultrasound: Q&A With Jeffrey S. Schweitzer, MD, PhD
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Joel A. Salinas, MD, MSc, MBA
Chief, McCance Brain Health Unit
Recent Article
MicroRNA From Whole Blood May Be Stroke Biomarker, Therapeutic Target
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Jonathan Rosand, MD
Co-Director, Henry and Allison McCance Center for Brain Health, Chief, Division of Neurocritical Care and Emergency Neurology, Medical Director, Neuroscience Intensive Care Unit
Recent Article
Special Report: The Bugher Network in Hemorrhagic Stroke
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Keith A. Johnson, MD
Radiologist
Recent Article
Tau PET Imaging May Help Identify People with Pre-symptomatic Alzheimer’s Disease
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Todd M. Herrington, MD, PhD
Director, Deep Brain Stimulation Program, Massachusetts General Hospital
Recent Article
Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease
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Yakeel T. Quiroz, PhD
Associate Professor, Harvard Medical School, Director, Familial Dementia Neuroimaging Lab, Director, Multicultural Alzheimer's Prevention Program, Massachusetts General Hospital, Paul B. and Sandra M. Edgerley MGH Research Scholar 2020-2025
Recent Article
Higher Levels of Education Buffer Against Autosomal Dominant Alzheimer's Disease
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.