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Featured
Cromolyn Sodium Provides Neuroprotection in Animal Model of ALS
Building on similar research in Alzheimer's disease, researchers at Massachusetts General Hospital demonstrated that treatment with cromolyn sodium delayed disease onset and was neuroprotective in a mouse model of amyotrophic lateral sclerosis by decreasing the inflammatory response.
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Featured
Case of Resistance to Autosomal Dominant Alzheimer's Disease Suggests New Direction for Treatment
A woman with autosomal dominant Alzheimer's disease had very late onset of mild cognitive impairment, apparently because she was homozygous for the APOE3 Christchurch mutation.
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Featured
Patterns of Neural Network Degradation Differ in Alzheimer's Disease and Normal Aging
Functional MRI may someday be able to distinguish the neurodegenerative changes related to early Alzheimer's disease from those of normal aging.
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Pre-symptomatic Intervention Is Rare in Neurodegenerative Disease Clinical Trials
Sonia M. Vallabh, PhD, Eric Vallabh Minikel, PhD, and Meredith A. Mortberg used two decades of clinical trial registration data to analyze the characteristics of trials in four major neurodegenerative diseases, finding only 2.7% of trials addressed preventive interventions.
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Gray to White Matter Signal Ratio Validated As Novel Biomarker of Neurodegeneration in Alzheimer's Disease
Deepti Putcha, PhD, Bradford C. Dickerson, MD, and colleagues have shown that the gray to white matter signal ratio on conventional MRI is additive to cortical thickness, and amyloid and tau deposition for detecting neuropathologic changes associated with early Alzheimer's disease.
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ALS Therapy Research and Development: Insights from Merit Cudkowicz, MD, MSc
Clinical trials of amyotrophic lateral sclerosis (ALS) therapeutic strategies coordinated through Massachusetts General Hospital are prolonging patient life.
Neurodegenerative Disease Contributors
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Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Novel Tandem CAR T-Cell Effective Against Heterogeneous Glioblastoma
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Ghazaleh Sadri-Vakili, MS, PhD
Assistant in Neuroscience, Massachusetts General Hospital, Assistant Professor of Neurology, Harvard Medical School
Recent Article
Novel Target Identified for Treatment of ALS
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Jeffrey S. Schweitzer, MD, PhD
Neurosurgeon
Recent Article
Patient-derived Dopamine Neurons Show Promise in Parkinson's Treatment
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Joel A. Salinas, MD, MSc, MBA
Chief, McCance Brain Health Unit
Recent Article
MicroRNA From Whole Blood May Be Stroke Biomarker, Therapeutic Target
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Jonathan Rosand, MD
Co-Director, Henry and Allison McCance Center for Brain Health, Chief, Division of Neurocritical Care and Emergency Neurology, Medical Director, Neuroscience Intensive Care Unit
Recent Article
Special Report: The Bugher Network in Hemorrhagic Stroke
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Keith A. Johnson, MD
Radiologist
Recent Article
Tau PET Imaging May Help Identify People with Pre-symptomatic Alzheimer’s Disease
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Todd M. Herrington, MD, PhD
Director, Deep Brain Stimulation Program, Massachusetts General Hospital
Recent Article
Patient-derived Dopamine Neurons Show Promise in Parkinson's Treatment
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Yakeel T. Quiroz-Gaviria, PhD
Associate Professor, Harvard Medical School, Director, Familial Dementia Neuroimaging Lab, Director, Multicultural Alzheimer's Prevention Program, Massachusetts General Hospital, Paul B. and Sandra M. Edgerley MGH Research Scholar 2020-2025
Recent Article
MRI Feature Is Marker of Disease Progression in Preclinical Autosomal Dominant Alzheimer's Disease
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.