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Featured
Collaboration in Developing New Cell Therapy
In this video, Bob S. Carter, MD, PhD, Kwang-Soo Kim, PhD, Todd M. Herrington, MD, PhD, and Jeffrey S. Schweitzer, MD, PhD, discuss their cross-disciplinary and multi-institutional collaboration to develop this new therapy.
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Featured
Gene Therapy Reverses Degeneration of the Retinal Pigment Epithelium in Preclinical Models
Gene therapy with Nrf2—a master transcription factor—preserves the retinal pigment epithelium in mouse models of retinitis pigmentosa, David M. Wu, MD, PhD, of the Department of Ophthalmology, and colleagues observed.
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Featured
Enhanced Interferon Signaling May Improve CAR T-cell Immunotherapy for Solid Tumors
Marcela V. Maus, MD, PhD, Rebecca C. Larson, PhD, and colleagues found that loss of genes in the interferon-gamma receptor signaling pathway is a mechanism of resistance to chimeric antigen receptor (CAR) T-cell therapy, suggesting a way to improve CAR T-cell treatment design for solid tumors.
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Novel AAV Capsid, Truncated ChAT Promoter Address Challenges in Intracranial Gene Therapy
Miguel C. Santoscoy, PhD, Casey A. Maguire, PhD, and colleagues have developed an adeno-associated virus capsid that transduces a broad area of the striatum upon intracranial injection in mice and a truncated human choline acetyltransferase promoter that allows efficient, selective transduction of cholinergic neurons.
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Cochlear Organoids Shed Light on Hair Cell Regeneration for Hearing Loss Treatment
Albert Edge, PhD, and colleagues have developed murine cochlear organoids that show how sensory epithelial progenitor cells differentiate into hair cells, a potential step toward developing regenerative therapies for human hearing loss.
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CRISPR-Cas9 Genome Editing Treats Genetic Hearing Loss by Promoting Outer Hair Cell Survival
Yong Tao, PhD, Veronica Lamas, PhD, and Zheng-Yi Chen, DPhil, have extended their previous murine research to show CRISPR-associated protein 9 (Cas9)-based genome editing can treat hearing loss associated with monogenic mutations in outer hair cell genes and digenic mutations affecting both inner and outer hair cells.
Gene and Cell Therapy Contributors
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Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease -
Jeffrey S. Schweitzer, MD, PhD
Neurosurgeon, Department of Neurosurgery, Massachusetts General Hospital, Assistant Professor of Neurosurgery, Harvard Medical School
Recent Article
Essential Tremor Treatment Advancements Using MRI-guided Focused Ultrasound: Q&A With Jeffrey S. Schweitzer, MD, PhD -
Jeremy Slade Abramson, MD
Director, Jon and JoAnn Hagler Center for Lymphoma, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School
Recent Article
Neutropenia-driven Approach to G-CSF Use May Be Feasible With CAR T-Cell Therapy -
Luk Vandenberghe, PhD
Associate Professor of Ophthalmology, Harvard Medical School, Grousbeck Family Chair in Gene Therapy and Director of the Grousbeck Gene Therapy Center, Mass Eye and Ear
Recent Article
Developing a Gene-based Vaccine Candidate for COVID-19 -
Marcela V. Maus, MD, PhD
Director, Cellular Immunotherapy Program, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School
Recent Article
Novel Tandem CAR T-Cell Effective Against Heterogeneous Glioblastoma -
Merit Ester Cudkowicz, MD, MSc
Chief, Neurology Service, Director of the Sean M. Healey & AMG Center for ALS at Mass General, Director of Neurological Clinical Research Institute and the Jilieane Dorn Professor of Neurology, Harvard Medical School
Recent Article
ALS Therapy Research and Development: Insights from Merit Cudkowicz, MD, MSc -
Priscilla K. Brastianos, MD
Director, Central Nervous System Metastasis Center, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School
Recent Article
ASCO 2024 Meeting Highlights -
Robert (Mark) Richardson, MD, PhD
Director of Functional Neurosurgery, Massachusetts General Hospital
Recent Article
Intracranial Stereo-EEG Resolves Discordant Clinical vs. Neuroimaging Findings in Patient With Tonic–Clonic Seizures -
Todd M. Herrington, MD, PhD
Director, Deep Brain Stimulation Program, Massachusetts General Hospital
Recent Article
Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease -
William T. Curry, MD
Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology, Massachusetts General Hospital, Adeline Rose Wydotis Professor of Neurosurgery, Harvard Medical School
Recent Article
Review: The Role of Antibody-Based Therapies in Neuro-Oncology -
Yakeel T. Quiroz, PhD
Associate Professor, Harvard Medical School, Director, Familial Dementia Neuroimaging Lab, Director, Multicultural Alzheimer's Prevention Program, Massachusetts General Hospital, Paul B. and Sandra M. Edgerley MGH Research Scholar 2020-2025
Recent Article
Higher Levels of Education Buffer Against Autosomal Dominant Alzheimer's Disease