-
Featured
Collaboration in Developing New Cell Therapy
In this video, Bob S. Carter, MD, PhD, Kwang-Soo Kim, PhD, Todd M. Herrington, MD, PhD, and Jeffrey S. Schweitzer, MD, PhD, discuss their cross-disciplinary and multi-institutional collaboration to develop this new therapy.
-
Featured
Gene Therapy Reverses Degeneration of the Retinal Pigment Epithelium in Preclinical Models
Gene therapy with Nrf2—a master transcription factor—preserves the retinal pigment epithelium in mouse models of retinitis pigmentosa, David M. Wu, MD, PhD, of the Department of Ophthalmology, and colleagues observed.
-
Featured
Enhanced Interferon Signaling May Improve CAR T-cell Immunotherapy for Solid Tumors
Marcela V. Maus, MD, PhD, Rebecca C. Larson, PhD, and colleagues found that loss of genes in the interferon-gamma receptor signaling pathway is a mechanism of resistance to chimeric antigen receptor (CAR) T-cell therapy, suggesting a way to improve CAR T-cell treatment design for solid tumors.
-
Innovations in Hearing and Vision Restoration Through Gene Therapy
Artur A. Indzhykulian, MD, PhD, is advancing gene therapies for sensory disorders like Usher syndrome, exploring innovative approaches to restore hearing, balance, and vision through cutting-edge research and cross-disciplinary collaboration.
-
Hematopoietic Stem-Cell Gene Therapy Restores White Matter Microvascular Function in Cerebral Adrenoleukodystrophy
Arne Lauer, MD, Patricia L. Musolino, MD, PhD, and colleagues found that ABCD1 gene therapy with autologous hematopoietic stem cells halts the progression of cerebral adrenoleukodystrophy at least in part because it improves microvascular circulation of the entire cerebral white matter.
-
Case Series: Intraventricular Infusion of Dual-targeting CAR T-Cells for Glioblastoma
Massachusetts General Hospital researchers showed rapid, dramatic radiographic responses in three patients with glioblastoma who received intraventricular infusion of CAR T-cells that targeted both EGFR variant III and wild-type EGFR. In two of the patients, however, the effects were transient.
Gene and Cell Therapy Contributors
-
Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease
-
Jeffrey S. Schweitzer, MD, PhD
Neurosurgeon, Department of Neurosurgery, Massachusetts General Hospital, Assistant Professor of Neurosurgery, Harvard Medical School
Recent Article
Essential Tremor Treatment Advancements Using MRI-guided Focused Ultrasound: Q&A With Jeffrey S. Schweitzer, MD, PhD
-
Jeremy Slade Abramson, MD
Director, Jon and JoAnn Hagler Center for Lymphoma, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School
Recent Article
Neutropenia-driven Approach to G-CSF Use May Be Feasible With CAR T-Cell Therapy
-
Luk Vandenberghe, PhD
Associate Professor of Ophthalmology, Harvard Medical School, Grousbeck Family Chair in Gene Therapy and Director of the Grousbeck Gene Therapy Center, Mass Eye and Ear
Recent Article
Developing a Gene-based Vaccine Candidate for COVID-19
-
Marcela V. Maus, MD, PhD
Director, Cellular Immunotherapy Program, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School
Recent Article
Case Series: Intraventricular Infusion of Dual-targeting CAR T-Cells for Glioblastoma
-
Merit Ester Cudkowicz, MD, MSc
Chief, Neurology Service, Director of the Sean M. Healey & AMG Center for ALS at Mass General, Director of Neurological Clinical Research Institute and the Jilieane Dorn Professor of Neurology, Harvard Medical School
Recent Article
ALS Therapy Research and Development: Insights from Merit Cudkowicz, MD, MSc
-
Priscilla K. Brastianos, MD
Director, Central Nervous System Metastasis Center, Mass General Cancer Center, Associate Professor of Medicine, Harvard Medical School
Recent Article
ASCO 2024 Meeting Highlights
-
Robert (Mark) Richardson, MD, PhD
Director of Functional Neurosurgery, Massachusetts General Hospital
Recent Article
Intracranial Stereo-EEG Resolves Discordant Clinical vs. Neuroimaging Findings in Patient With Tonic–Clonic Seizures
-
Todd M. Herrington, MD, PhD
Director, Deep Brain Stimulation Program, Massachusetts General Hospital
Recent Article
Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease
-
William T. Curry, MD
Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology, Massachusetts General Hospital, Adeline Rose Wydotis Professor of Neurosurgery, Harvard Medical School
Recent Article
Review: The Role of Antibody-Based Therapies in Neuro-Oncology
-
Yakeel T. Quiroz, PhD
Associate Professor, Harvard Medical School, Director, Familial Dementia Neuroimaging Lab, Director, Multicultural Alzheimer's Prevention Program, Massachusetts General Hospital, Paul B. and Sandra M. Edgerley MGH Research Scholar 2020-2025
Recent Article
Higher Levels of Education Buffer Against Autosomal Dominant Alzheimer's Disease
