Posts by Jeremy Slade Abramson, MD
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Neutropenia-driven Approach to G-CSF Use May Be Feasible With CAR T-Cell Therapy
Mass General Cancer Center researchers found using granulocyte colony-stimulating factor to treat neutropenia after chimeric antigen receptor T-cell therapy, rather than as prophylaxis, resulted in less risk of severe cytokine release syndrome (CRS). Initiating G-CSF after CRS onset did not exacerbate toxicity.
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Phase 1 Trial Supports Safety and Efficacy of Novel CAR-T Therapy for Large B-cell Lymphomas
Lisocabtagene maraleucel, an investigational CAR T-cell product, was linked to low incidence of cytokine release syndrome and neurological events in a phase 1 seamless design pivotal trial and often led to rapid and durable remission among patients with high-risk relapsed/refractory large B-cell lymphoma.
Biography
Dr. Abramson is Director of the Lymphoma Program and the Jon and Jo Ann Hagler Chair in Lymphoma at the Massachusetts General Hospital Cancer Center. He is also Associate Professor of Medicine at Harvard Medical School. Dr. Abramson earned his medical degree from the Mount Sinai School of Medicine in New York City and a Masters Degree in Medical Sciences from Harvard Medical School. He completed a residency in Internal Medicine at the Massachusetts General Hospital in Boston, followed by a fellowship in Hematology and Oncology at the Dana-Farber Cancer Institute. Dr. Abramson is board certified in Medical Oncology.
Dr. Abramson's clinical and research interests are in lymphoid malignancies, including all non-Hodgkin lymphomas, as well as Hodgkin lymphoma, and chronic lymphoid leukemias. His research involves identifying new targets for therapy in lymphomas and lymphoid leukemias, and the design and conduct of clinical trials of new cancer therapies and cellular immunotherapies in these diseases. He is a member of the American Society of Hematology, the American Society of Clinical Oncology, and a Fellow of the American College of Physicians. Dr. Abramson is the author of numerous papers and book chapters on lymphoma, and lectures widely.
Mass General Cancer Center
An integral part of one of the world’s most distinguished academic medical centers, the Massachusetts General Hospital Cancer Center is among the leading cancer care providers in the United States.
