Posts by Robert (Mark) Richardson, MD, PhD
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Intracranial Stereo-EEG Resolves Discordant Clinical vs. Neuroimaging Findings in Patient With Tonic–Clonic Seizures
Irfan S. Sheikh, MD, Mark Richardson, MD, PhD, Sydney S. Cash, MD, PhD, and colleagues present an instructive case in which intracranial stereo-EEG resolved discordance between clinical, MRI, and scalp EEG findings, allowing diagnosis of focal cortical dysplasia type 2b and resection that led to seizure freedom.
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Barques Are Generated in Posterior Human Hippocampus
Vasileios Kokkinos, PhD, Mark Richardson, MD, PhD, and colleagues have determined that barques—variant findings on intracranial EEG—are highly specific to the posterior human hippocampus, an important observation for differentiating barques from interictal epileptic activity.
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Speech-induced Artifacts Can Contaminate Intracranial Recordings in Awake Patients
Alan Bush, PhD, and Mark Richardson, MD, PhD, of the Department of Neurosurgery, and colleagues identified speech-induced artifacts in intracranial recordings obtained during a speech production task. They show the artifacts were caused by mechanical vibrations and give pointers for identifying them.
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Hippocampal Spindles and Barques Are Normal Intracranial EEG Entities
Vasileios Kokkinos, PhD, and R. Mark Richardson, MD, PhD, of the Department of Neurosurgery, and colleagues have conducted the first direct testing that demonstrates hippocampal spindles and barques on intracranial EEG are normal findings.
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Mass General Renews Focus on Pediatric Epilepsy
A new team approach at Mass General is applying advances in adult epileptics, such as epilepsy surgery and responsive neurostimulation, to children.
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Extrapial Hippocampal Resection in Anterior Temporal Lobectomy for Drug-Resistant Temporal Lobe Epilepsy
Mark Richardson, MD, PhD, of the Department of Neurosurgery, and colleagues describe an extrapial approach to hippocampal resection in anterior temporal lobectomy for treatment of drug-resistant temporal lobe epilepsy that has proven to be safe and as effective as subpial techniques.
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Case Report: Responsive Neurostimulation for Treatment of Super-Refractory Status Epilepticus
Physicians at Massachusetts General Hospital have demonstrated the novel, effective use of responsive neurostimulation for treating status epilepticus in a patient who did not respond to antiepileptic drugs, immunomodulatory therapy, ketogenic diet or transcranial magnetic stimulation.
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Forming a Collaboration Between Neurosurgeons and Neuroscientists
Mark Richardson, MD, PhD, director of the Functional Neurosurgery Program in the Department of Neurosurgery at Massachusetts General Hospital, talks about his collaboration with MIT. Researchers from both institutions will create an information warehouse to advance data science.
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Moving the Field of Epilepsy Therapy Forward
In this video, Mark Richardson, MD, PhD, director of the Functional Neurosurgery Program, details when patients should consult a comprehensive epilepsy center and the ways in which Massachusetts General Hospital tailors treatments to the patient's epilepsy.
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The Precision and Safety of Deep Brain Stimulation
Mark Richardson, MD, PhD, director of Functional Neurosurgery in the Department of Neurosurgery, discusses the evolution and successful use of deep brain stimulation to treat those with Parkinson's disease and dystonia, and the use of robotics to enhance surgical outcomes.
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Location of Deep Brain Stimulation in Parkinson's Disease Patients Affects Postoperative Voice Quality
In patients with Parkinson's disease who underwent deep brain stimulation, improvements in perceptual, acoustic and aerodynamic voice measures were likely if electrodes were placed in the anterior sensorimotor region of the left subthalamic nucleus.
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Using MRI to Deliver Gene Therapy for Parkinson's Disease
Massachusetts General Hospital is launching a trial of a therapeutic enzyme for Parkinson's disease using intraoperative MRI for more accurate drug delivery in the brain.
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Timing of Activity in the Basal Ganglia Is More Important to Movement than Firing Rates
Intraoperative electrophysiological data from patients with Parkinson's disease show that just prior to movement on a handgrip task, there was elevated subthalamic nucleus spike-to-cortical gamma phase coupling that preceded faster reaction times.
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Functional Neurosurgeons Innovate New Methods for Improved Patient Care
Specialists at Massachusetts General Hospital's Functional Neurosurgery Division link research and clinical excellence to innovate care.
Biography
Dr. Richardson completed the MD-PhD program at Virginia Commonwealth University’s Medical College of Virginia and neurosurgical residency at the University of California, San Francisco. His clinical expertise includes both awake and asleep DBS for movement disorders, psychiatric indications, and epilepsy, awake brain mapping, robotic-assisted surgery for both stereo-EEG and DBS implantation, and Responsive Neurostimulation for epilepsy. Prior to joining Mass General, Dr. Richardson was Director of the Epilepsy and Movement Disorders Surgery Program at the University of Pittsburgh Medical Center (UPMC). There, he established one of the world's leading intraoperative-MRI functional neurosurgery programs, encompassing DBS for movement disorders, gene therapy clinical trials for Parkinson’s disease, and laser thermal ablation for epilepsy, work which now continues at MGH.
Dr. Richardson is recognized internationally for his work, having published numerous related papers and book chapters, and frequently speaking at national and international meetings. He is a member of the Executive Board of the American Society for Stereotactic and Functional Neurosurgery.
Dr. Richardson also is a neuroscientist who founded the Brain Modulation Lab, which conducts human systems neuroscience research using intracranial recording and stimulation.
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.