TopicLung Cancer

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Maximizing Clinical Utility of Pulmonary Optical Imaging

Massachusetts General Hospital researchers push the limits of pulmonary optical frequency domain imaging for in vivo diagnosis of lung cancer and assessment of asthmatic airways.

Asthma, Lung Cancer, Oncology, Pulmonary and Critical Care, Radiology, Thoracic Imaging

Article January 21, 2021

Smoking History Predicts Efficacy of Immune Checkpoint Inhibitors in Metastatic Non–Small-Cell Lung Cancer

David C. Christiani, MD, MPH, and colleagues suggest smoking history as an independent surrogate for tumor mutation burden when deciding which patients with advanced non–small-cell lung cancer would benefit from immune checkpoint inhibitor therapy, as smoking pack-years complemented PD-L1 tumor proportion score.

Lung Cancer, Pulmonary and Critical Care

Journal May 23, 2023

Paclitaxel-loaded Mesh Reduces Local Recurrence of Lung Cancer in Animal Model

Yolonda L. Colson, MD, PhD, and colleagues have developed a polymer mesh that can be loaded with a chemotherapeutic agent and implanted during resection to prevent local recurrence. Its use significantly improved survival in a mouse model of non–small-cell lung cancer.

Lung Cancer, Oncology, Pulmonary and Critical Care, Thoracic Surgery

Journal May 22, 2023

New AI Tool Predicts Six-Year Lung Cancer Risk From a Single CT Scan

Lecia V. Sequist, MD, MPH, Florian J. Fintelmann, MD, and colleagues have created and validated Sybil, a convolutional neural network that requires only one low-dose CT scan to predict future lung cancer, regardless of whether visible lung nodules are present and possibly independent of the patient's smoking history.

Lung Cancer, Oncology, Pulmonary and Critical Care

Journal April 13, 2023

Health-related Quality of Life Among Unmarried Patients Diagnosed With Lung Cancer Worse During COVID-19 Than Before

Laura A. Petrillo, MD, Joseph A. Greer, PhD, and colleagues report the COVID-19 pandemic is not further reducing health-related quality of life (HRQOL) or exacerbating depression among patients with advanced lung cancer. Still, HRQOL is worse among unmarried patients, driven by declines in functional well-being.

COVID-19, Depression, Geriatrics and Palliative Care, Lung Cancer, Patient-Reported Outcome Measures

Journal February 28, 2023

Review: Managing Lung Cancer in Patients With Interstitial Lung Disease

Massachusetts General Hospital researchers recently summarized evidence about the risk of lung cancer in patients with interstitial lung disease (ILD), considerations for diagnosis and treatment of lung cancer in that population, and monitoring for ILD progression during lung cancer treatment.

Lung Cancer, Oncology, Pulmonary and Critical Care

Journal February 16, 2023