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Featured
Brain Infection with Herpes Virus May Accelerate Progression of Alzheimer's Disease
Laboratory studies at Mass General suggest that active herpes infections in the brain may accelerate amyloid deposition and the progression of Alzheimer's disease.
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Featured
Scientists Identify Steps Needed to Address Disparities in Dementia Research and Care
According to a white paper sponsored by the Alzheimer's Association, dementia scientists must stop neglecting the need for research on underrepresented ethnic and racial groups.
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Featured
Tau PET Imaging May Help Identify People with Pre-symptomatic Alzheimer’s Disease
Brain changes associated with Alzheimer’s disease can now be studied in living people. Mass General researchers imaged cognitively normal people who are destined to develop AD due to a rare genetic mutation. Their goal: to discover how soon brain changes are present before symptoms begin and how soon preventive treatments could be initiated.
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Co-Occurring Cardiovascular/Metabolic Abnormalities Linked to Widespread Alterations In Brain Connectivity
Barnaly Rashid, PhD, Steven E. Arnold, MD, and colleagues report that, across the adult lifespan, worse cardiometabolic health associates with dysregulated functional connectivity throughout the brain, including in higher-order brain networks vital to cognitive function. The effect was strongest in adults under age 65.
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Performance on Test of Semantic Abilities Linked to Early Alzheimer's Disease Brain Pathology
In not-yet-demented carriers of a mutation that inevitably causes Alzheimer's disease (AD), Massachusetts General Hospital researchers found a significant link between "clustering" on a category fluency test and brain levels of amyloid and tau, suggesting cognitive testing might someday detect early or preclinical AD.
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Gray to White Matter Signal Ratio Validated As Novel Biomarker of Neurodegeneration in Alzheimer's Disease
Deepti Putcha, PhD, Bradford C. Dickerson, MD, and colleagues have shown that the gray to white matter signal ratio on conventional MRI is additive to cortical thickness, and amyloid and tau deposition for detecting neuropathologic changes associated with early Alzheimer's disease.
Alzheimer's Disease Contributors
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Keith A. Johnson, MD
Radiologist
Recent Article
Tau PET Imaging May Help Identify People with Pre-symptomatic Alzheimer’s Disease
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Robert Moir, PhD
Assistant Professor in Neurology, Massachusetts General Hospital
Recent Article
The Innate Immune Protection Hypothesis of Alzheimer's Disease -
Rudolph E. Tanzi, PhD
Joseph P. and Rose F. Kennedy Professor of Neurology, Harvard Medical School, Vice-Chair, Massachusetts General Hospital Neurology Department, Co-Director of the McCance Center for Brain Health, Massachusetts General Hospital
Recent Article
How Amyloid-beta Forms Suggests New Strategies for Preventing, Treating Alzheimer's Disease
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Se Hoon Choi, PhD
Assistant Professor of Neurology, Massachusetts General Hospital
Recent Article
New Model Allows Screening of Drugs to Improve Blood–Brain Barrier Integrity in Alzheimer's Disease -
Yakeel T. Quiroz, PhD
Associate Professor, Harvard Medical School, Director, Familial Dementia Neuroimaging Lab, Director, Multicultural Alzheimer's Prevention Program, Massachusetts General Hospital, Paul B. and Sandra M. Edgerley MGH Research Scholar 2020-2025
Recent Article
Performance on Test of Semantic Abilities Linked to Early Alzheimer's Disease Brain Pathology
Neuroscience Care at Mass General
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