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Posts by Rudolph E. Tanzi, PhD


The focus of Dr. Tanzi's research is in identifying and characterizing the genetic and environmental factors involved in neurodegeneration in Alzheimer's disease in autism. In addition to identifying risk factors for Alzheimer's disease, he and his colleagues address the mechanisms underlying the etiology and pathogenicity of the genes responsible for Alzheimer's disease through the application of molecular, cell biological, and biochemical strategies.

Dr. Tanzi's ongoing research in AD and autism follows a basic roadmap, which includes disease gene discovery, translational and functional studies to identify pathogenic gene variants and mutations, molecular biological and biochemical studies to elucidate pathways that have been impacted by disease-associated gene changes, and novel drug screening assays to identify small molecules or supplements that can halt or reverse pathogenic molecular and biochemical phenotypes at the cellular level.