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As an immunologist and infectious disease specialist, Jay Vyas, MD, PhD focuses on basic investigations of host-pathogen interactions. Dr. Vyas has a long-standing interest in immune response to infections. His laboratory focuses on the innate immune responses to clinically relevant fungal pathogens. They employ both cell biological and biochemical tools to understand the molecular mechanisms that govern host immunity to these microorganisms. Using mouse models with defined defects in innate immunity, they have described key mechanisms that orchestrate this immune response to fungal infections.

Dr. Vyas also serves as the 10th Program Director of the Massachusetts General Hospital Department of Medicine Residency Program. He currently supervises 168 interns and residents. As an NIH-funded investigator with interests in basic science, he provides a unique perspective to the medical housestaff. Outstanding clinical care is fueled by basic discovery and the greatest opportunities to improve patient care comes from high-quality research.