Posts by David Christopher Christiani, MD, MPH
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Pulmonary Function at Time of Lung Cancer Diagnosis Has Prognostic Value
David C. Christiani, MD, MPH, and colleagues found in a large cohort of patients newly diagnosed with non–small-cell lung cancer that poorer spirometry results were linearly associated with worse survival, even after accounting for age, sex, smoking status, tumor histology, cancer stage, and types of treatment.
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Smoking History Predicts Efficacy of Immune Checkpoint Inhibitors in Metastatic Non–Small-Cell Lung Cancer
David C. Christiani, MD, MPH, and colleagues suggest smoking history as an independent surrogate for tumor mutation burden when deciding which patients with advanced non–small-cell lung cancer would benefit from immune checkpoint inhibitor therapy, as smoking pack-years complemented PD-L1 tumor proportion score.
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Machine Learning Algorithm Leverages Use of EHRs for Lung Cancer Research
Using electronic health records, a machine learning algorithm and natural language processing, researchers at Massachusetts General Hospital assembled a large cohort that to study lung cancer progression and developed an electronic tool capable of predicting survival in non–small cell lung cancer.
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Biological Insights into ARDS May Improve Treatment of COVID-19
By integrating genomic and transcriptomic data, David C. Christiani, MD, MPH, of the Pulmonary and Critical Care Unit, and colleagues gleaned information about the pathogenesis of acute respiratory distress syndrome (ARDS) and potential genetic targets for therapies, including therapies for COVID-19–related ARDS.
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Prevalence of Erythropoietic Protoporphyria Has Been Underestimated
An analysis of the UK Biobank shows the prevalence of erythropoietic protoporphyria is 2.3 times higher than previously estimated in Europe, according to the first analysis of a large genetic data set.
Biography
David Christiani, MD, MPH, is medical director of the Christiani Lab in the Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital. A staff physician in the Mass General Pulmonary and Critical Care Unit, Dr. Christiani is also a professor of medicine at Harvard Medical School and the Elkan Blout Professor of Environmental Genetics at the Harvard School of Public Health. In addition, he directs the environmental and occupational medicine section of the Mass General Division of Pulmonary and Critical Care Medicine. His major research interests are gene-environment interactions in acute and chronic illness. He has been active in developing new methods for assessing health effects after exposure to pollutants, incorporating genetic studies in environmental health and introducing genetic studies into the critical-care setting. His interest in global environmental health dates back 30 years, and he has led or co-led international collaborative studies in Asia, Africa and Latin America.
Pulmonary and Critical Care Medicine
The Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital provides comprehensive care for the full range of respiratory conditions and diseases.