Posts by Charles Corey Hardin, MD, PhD
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Commentary: Widely Reported Study of Therapeutic Anticoagulation for COVID-19 Has Serious Flaws
The report of an association between therapeutic anticoagulation and in-hospital survival among patients with COVID-19 has several serious limitations, including immortal time bias.
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No Evidence to Support Novel Mechanism of Hypoxemia in COVID-19
According to Massachusetts General Hospital clinicians, observations of hypoxemia in COVID-19 are entirely consistent with known mechanisms and do not require the invocation of novel processes specific to SARS-CoV-2.
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Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19 Is Typical of ARDS
Massachusetts General Hospital researchers find that patients with COVID-19 respiratory failure exhibited gas exchange, respiratory system mechanics and response to prone ventilation similar to that of prior large cohorts of patients with ARDS.
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Surfactant Worth Studying as Treatment for COVID-19–Related ARDS
Massachusetts General Hospital researchers believe COVID-19 may represent an unexpected but worthwhile opportunity to revisit the therapeutic potential of administering exogenous surfactant to adults with acute respiratory distress syndrome.
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Unconventional Ventilation Strategies Not Recommended for COVID-19–Related ARDS
Massachusetts General Hospital researchers explain that neither airway pressure release ventilation nor high-frequency oscillatory ventilation has been shown to improve mortality for patients with acute respiratory distress syndrome.
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COVID-19 Does Not Lead to "Atypical" ARDS
Arguments that COVID-19–associated respiratory failure is something other than acute respiratory distress syndrome (ARDS) are not supported by data or in-depth explanation.
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Alveolar Recruitment in Patients with ARDS Related to COVID-19
In patients with acute respiratory distress syndrome related to COVID-19, care must be taken to choose the positive end-expiratory pressure that opens alveoli without over-distending the large amount of normal lung.
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Didactic and Q&A: How to Care for Critically Ill Patients
The Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital held a virtual didactic and Q&A session on best practices for caring for critically-ill patients.
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Inhaled Nitric Oxide Preferred to Epoprostenol in COVID-19 as Rescue Therapy
Despite frequent use in patients with acute respiratory distress syndrome, inhaled pulmonary vasodilators have never been shown to improve survival.
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Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Patients
In this Q&A, Lorenzo Berra, MD, and Charles Hardin, MD, PhD, of Massachusetts General Hospital explain the link between acute respiratory distress syndrome (ARDS) and share insight into upcoming research on antiviral treatment approaches.
Pulmonary and Critical Care Medicine
The Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital provides comprehensive care for the full range of respiratory conditions and diseases.Related Links
