Massachusetts General Hospital physicians have identified two phenotypes of acute respiratory distress syndrome (ARDS) associated with COVID-19 that are distinct in biochemical profiles and short-term mortality despite minimal differences in respiratory dynamics.
Commenting on a recent pre-clinical study, C. Corey Hardin, MD, PhD, of the Division of Pulmonary and Critical Care Medicine, and a colleague explain why applying titrated positive end-expiratory pressure in the prone position helps protect the lungs of patients with acute respiratory distress syndrome.
Massachusetts General Hospital physicians have published guidance on treating critically ill adults with COVID-19 that synthesizes the pre-existing critical care literature with emerging data from observational reports and randomized controlled trials.
According to Massachusetts General Hospital clinicians, observations of hypoxemia in COVID-19 are entirely consistent with known mechanisms and do not require the invocation of novel processes specific to SARS-CoV-2.
Massachusetts General Hospital researchers find that patients with COVID-19 respiratory failure exhibited gas exchange, respiratory system mechanics and response to prone ventilation similar to that of prior large cohorts of patients with ARDS.
Massachusetts General Hospital researchers believe COVID-19 may represent an unexpected but worthwhile opportunity to revisit the therapeutic potential of administering exogenous surfactant to adults with acute respiratory distress syndrome.
Massachusetts General Hospital researchers explain that neither airway pressure release ventilation nor high-frequency oscillatory ventilation has been shown to improve mortality for patients with acute respiratory distress syndrome.
In patients with acute respiratory distress syndrome related to COVID-19, care must be taken to choose the positive end-expiratory pressure that opens alveoli without over-distending the large amount of normal lung.
In this Q&A, Lorenzo Berra, MD, and Charles Hardin, MD, PhD, of Massachusetts General Hospital explain the link between acute respiratory distress syndrome (ARDS) and share insight into upcoming research on antiviral treatment approaches.