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Featured
Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes
Most genome-wide association studies (GWAS) are likely to miss variants with recessive effects. In a large recessive-model GWAS, Massachusetts General Hospital researchers identified a novel locus associated with 2.56 greater risk of type 2 diabetes in homozygous carriers that also had substantial effects on lipids.
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Bionic Pancreas Improves Glycemic Control in Patients With Cystic Fibrosis-related Diabetes
Melissa Putman, MD, Jordan Sherwood, MD, and colleagues report that the insulin-only iLet bionic pancreas improved glucose control in patients with cystic fibrosis-related diabetes (CFRD) compared to usual care, without an increase in continuous glucose monitoring-measured hypoglycemia.
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HbA1c Levels >6.6% Linked to Greater Risk of Repeat Surgery After ACL Reconstruction
Ophelie Lavoie-Gagne, MD, Miho J. Tanaka, MD, PhD, and colleagues conducted the first study of how preoperative glycemic control affects outcomes of ACL reconstruction, finding HbA1c ≥6.7% increases the risk of any surgical complication by 66% and increases the need for reoperation for surgical complications by 45%.
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Continuous Glucose Monitoring Predicts Long-term Nutritional Outcomes in Adults With Cystic Fibrosis
Melissa S. Putman, MD, and colleagues correlated findings on continuous glucose monitoring with a decline in body weight and a decline in body mass index over one year in adults with cystic fibrosis. Their data also suggest advanced glycation end products may represent a useful marker in this population.
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Cardiorenal Biomarkers Predict Major Complications in Patients With Type 2 Diabetes and Chronic Kidney Disease
James L. Januzzi, MD, and colleagues showed that among people with type 2 diabetes and albuminuria, baseline and follow-up concentrations of four biomarkers of cardiorenal stress individually and collectively predicted the risk of heart failure, progression of kidney disease, and related outcomes.
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Tobacco Use and Type 2 Diabetes Have Additive Effect on Risk of Fibrosis in Patients With MASLD
Oluwafemi Balogun, MBBS, MPH, Kathleen E. Corey, MD, MPH, MMSc, and colleagues demonstrated that smoking and underlying type 2 diabetes mellitus (T2DM) have a synergistic effect on the severity of fibrosis, nearly doubling the risk (OR, 1.88; P=0.0037) compared with nonsmokers who do not have T2DM.
Diabetes Contributors
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Camille E. Powe, MD
Endocrinologist, Massachusetts General Hospital, Co-Director, Diabetes in Pregnancy Program
Recent Article
Carbohydrate Intake Before Oral Glucose Tolerance Test May Prevent Accurate Diagnosis of Gestational Diabetes
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Jose C. Florez, MD, PhD
Chief, Diabetes Unit, Endocrine Division, John T. Potts Jr., MD Endowed Chair in Medicine, Massachusetts General Hospital, Professor of Medicine, Harvard Medical School
Recent Article
Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes
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Josep M. Mercader, PhD
Research-Scientist, Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital
Recent Article
Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients -
Melissa S. Putman, MD
Endocrinologist, Massachusetts General Hospital, Assistant Professor of Pediatrics, Harvard Medical School
Recent Article
Bionic Pancreas Improves Glycemic Control in Patients With Cystic Fibrosis-related Diabetes -
Si Arn Aaron Leong, MD, MSc
Endocrinologist, Diabetes Unit, Massachusetts General Hospital
Recent Article
Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients
Endocrinology Division
The Endocrinology Division at Massachusetts General Hospital offers a comprehensive integrated program of clinical services for both primary and tertiary care of adults with endocrine disorders.