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Featured
Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes
Most genome-wide association studies (GWAS) are likely to miss variants with recessive effects. In a large recessive-model GWAS, Massachusetts General Hospital researchers identified a novel locus associated with 2.56 greater risk of type 2 diabetes in homozygous carriers that also had substantial effects on lipids.
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Younger Age, Albuminuria Linked to Advanced Diabetic Retinopathy in South India
Lucia Sobrin, MD, MPH, and her co-principal investigators conducted a large population-based study in South India and found that younger age, male sex, longer duration of diabetes, higher hemoglobin A1c, and albuminuria are key non-genetic risk factors for proliferative diabetic retinopathy, and diabetic macular edema.
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Medical Grand Rounds: Results of the Glycemia Reduction Approaches in Diabetes Study
In a recent Medical Grand Rounds presentation, the Endocrine Division at Massachusetts General Hospital presented major results of the Glycemia Reduction Approaches in Diabetes—A Comparative Effectiveness (GRADE) study, designed to help guide the choice of glucose-lowering medications added to metformin.
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Transcatheter Arterialization of Deep Veins Safe, Successful for No-Option Chronic Limb-threatening Ischemia
Anahita Dua, MD, MBA, MSc, and colleagues found that transcatheter arterialization of the deep veins was safe and could be performed with a high degree of procedural success in patients with chronic limb-threatening ischemia who had no conventional revascularization options and would likely be amputated.
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Body Fat Distribution Affects Risk of Cardiometabolic Disease
Based on data UK Biobank, Amit V. Khera, MD, MSc, and colleagues used a machine learning approach to measure visceral (VAT), abdominal subcutaneous (ASAT), and gluteofemoral (GFAT) adipose tissue volumes with high accuracy.
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Changes in Insulin Receptor Condensates Contribute to Insulin Resistance
Jesse M. Platt, PhD, MD, and colleagues discovered that insulin receptor forms condensates and detailed how changes in the physio-mechanical features of insulin receptor condensates affect insulin resistance, showing that insulin receptor condensates are key for insulin signaling, become dysfunctional in insulin resistance and thus could be new targets for diabetes drugs.
Diabetes Contributors
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Camille E. Powe, MD
Endocrinologist, Massachusetts General Hospital, Co-Director, Diabetes in Pregnancy Program
Recent Article
Carbohydrate Intake Before Oral Glucose Tolerance Test May Prevent Accurate Diagnosis of Gestational Diabetes
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Jose C. Florez, MD, PhD
Chief, Diabetes Unit, Endocrine Division, John T. Potts Jr., MD Endowed Chair in Medicine, Massachusetts General Hospital, Professor of Medicine, Harvard Medical School
Recent Article
Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes
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Josep M. Mercader, PhD
Research-Scientist, Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital
Recent Article
Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients -
Melissa S. Putman, MD
Endocrinologist, Massachusetts General Hospital, Assistant Professor of Pediatrics, Harvard Medical School
Recent Article
Continuous Glucose Monitoring Shows Promise for Diagnosis of Cystic Fibrosis–Related Diabetes -
Si Arn Aaron Leong, MD, MSc
Endocrinologist, Diabetes Unit, Massachusetts General Hospital
Recent Article
Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients
Endocrinology Division
The Endocrinology Division at Massachusetts General Hospital offers a comprehensive integrated program of clinical services for both primary and tertiary care of adults with endocrine disorders.