-
Featured
Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes
Most genome-wide association studies (GWAS) are likely to miss variants with recessive effects. In a large recessive-model GWAS, Massachusetts General Hospital researchers identified a novel locus associated with 2.56 greater risk of type 2 diabetes in homozygous carriers that also had substantial effects on lipids.
-
Cardiorenal Biomarkers Predict Major Complications in Patients With Type 2 Diabetes and Chronic Kidney Disease
James L. Januzzi, MD, and colleagues showed that among people with type 2 diabetes and albuminuria, baseline and follow-up concentrations of four biomarkers of cardiorenal stress individually and collectively predicted the risk of heart failure, progression of kidney disease, and related outcomes.
-
Tobacco Use and Type 2 Diabetes Have Additive Effect on Risk of Fibrosis in Patients With MASLD
Oluwafemi Balogun, MBBS, MPH, Kathleen E. Corey, MD, MPH, MMSc, and colleagues demonstrated that smoking and underlying type 2 diabetes mellitus (T2DM) have a synergistic effect on the severity of fibrosis, nearly doubling the risk (OR, 1.88; P=0.0037) compared with nonsmokers who do not have T2DM.
-
Psychological and Behavioral Factors Identified That Predict Success of Lifestyle Interventions for Weight Loss
Massachusetts General Hospital researchers identified improvements in autonomous motivation, dietary self-regulation, and low-fat diet as the most important predictors of weight loss during a two-year lifestyle intervention, but only improvements in low-fat diet and depression were important after a year of follow-up.
-
Study Positions SGLT2 Inhibitors as Gout Treatment
A Massachusetts General Hospital research team has found that SGLT2 inhibitor therapy reduces gout flares and lowers the risk of myocardial infarction in patients with diabetes.
-
Younger Age, Albuminuria Linked to Advanced Diabetic Retinopathy in South India
Lucia Sobrin, MD, MPH, and her co-principal investigators conducted a large population-based study in South India and found that younger age, male sex, longer duration of diabetes, higher hemoglobin A1c, and albuminuria are key non-genetic risk factors for proliferative diabetic retinopathy, and diabetic macular edema.
Diabetes Contributors
-
Camille E. Powe, MD
Endocrinologist, Massachusetts General Hospital, Co-Director, Diabetes in Pregnancy Program
Recent Article
Carbohydrate Intake Before Oral Glucose Tolerance Test May Prevent Accurate Diagnosis of Gestational Diabetes -
Jose C. Florez, MD, PhD
Chief, Diabetes Unit, Endocrine Division, John T. Potts Jr., MD Endowed Chair in Medicine, Massachusetts General Hospital, Professor of Medicine, Harvard Medical School
Recent Article
Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes -
Josep M. Mercader, PhD
Research-Scientist, Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital
Recent Article
Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients -
Melissa S. Putman, MD
Endocrinologist, Massachusetts General Hospital, Assistant Professor of Pediatrics, Harvard Medical School
Recent Article
Continuous Glucose Monitoring Shows Promise for Diagnosis of Cystic Fibrosis–Related Diabetes -
Si Arn Aaron Leong, MD, MSc
Endocrinologist, Diabetes Unit, Massachusetts General Hospital
Recent Article
Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients