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Featured
Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes
Most genome-wide association studies (GWAS) are likely to miss variants with recessive effects. In a large recessive-model GWAS, Massachusetts General Hospital researchers identified a novel locus associated with 2.56 greater risk of type 2 diabetes in homozygous carriers that also had substantial effects on lipids.
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Changes in Insulin Receptor Condensates Contribute to Insulin Resistance
Jesse M. Platt, PhD, MD, and colleagues discovered that insulin receptor forms condensates and detailed how changes in the physio-mechanical features of insulin receptor condensates affect insulin resistance, showing that insulin receptor condensates are key for insulin signaling, become dysfunctional in insulin resistance and thus could be new targets for diabetes drugs.
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Diabetes Not a Risk Factor for Septic Shock Among Patients With Ureteral Stone and UTI
Jason Lee, MD, Brian H. Eisner, MD, and colleagues found the quick Sequential Organ Failure Assessment (qSOFA) may demonstrate false-positive results in predicting septic shock among patients with diabetes who have ureteral stones and concomitant infection, and diabetes was not an overall risk factor for septic shock.
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Mass General Leads Pivotal Trial of Bionic Pancreas
The novel iLet® Bionic Pancreas, developed and tested by Massachusetts General Hospital researchers, simplifies diabetes management and leads to better glucose control than currently available methods.
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Exercise May Improve Bone Health in Youth With Type 1 Diabetes
Massachusetts General Hospital researchers conducted a study analyzing bone health in young individuals with and without type 1 diabetes. They found that individuals with diabetes who exercised less had worse markers of bone health compared to those without diabetes.
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Innovative Procedure for Peripheral Artery Disease: Q&A With Dr. Anahita Dua, MBChB, MBA, MSc
Diabetes can cause peripheral artery disease, where blood flow to the legs and feet is reduced. These patients typically have amputations. Mass General researchers, including Anahita Dua, MBChB, MBA, MSc, are using a new, cutting-edge procedure to direct oxygenated blood to the foot, reducing the need for amputation.
Diabetes Contributors
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Camille E. Powe, MD
Endocrinologist, Massachusetts General Hospital, Co-Director, Diabetes in Pregnancy Program
Recent Article
Carbohydrate Intake Before Oral Glucose Tolerance Test May Prevent Accurate Diagnosis of Gestational Diabetes
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Jose C. Florez, MD, PhD
Chief, Diabetes Unit, Endocrine Division, John T. Potts Jr., MD Endowed Chair in Medicine, Massachusetts General Hospital, Professor of Medicine, Harvard Medical School
Recent Article
Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes
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Josep M. Mercader, PhD
Research-Scientist, Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital
Recent Article
Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients -
Melissa S. Putman, MD
Endocrinologist, Massachusetts General Hospital, Assistant Professor of Pediatrics, Harvard Medical School
Recent Article
Continuous Glucose Monitoring Shows Promise for Diagnosis of Cystic Fibrosis–Related Diabetes -
Si Arn Aaron Leong, MD, MSc
Endocrinologist, Diabetes Unit, Massachusetts General Hospital
Recent Article
Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients
Endocrinology Division
The Endocrinology Division at Massachusetts General Hospital offers a comprehensive integrated program of clinical services for both primary and tertiary care of adults with endocrine disorders.