Posts by Si Arn Aaron Leong, MD, MSc
Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients
Philip H. Schroeder, Josep M. Mercader, PhD, Aaron Leong, MD, MSc, and colleagues identified a set of protein biomarkers that provides insight into how cardiometabolic disease contributes to COVID-19 pathology—and helps predict which patients hospitalized with COVID-19 are at highest risk of severe illness.
Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes
Most genome-wide association studies (GWAS) are likely to miss variants with recessive effects. In a large recessive-model GWAS, Massachusetts General Hospital researchers identified a novel locus associated with 2.56 greater risk of type 2 diabetes in homozygous carriers that also had substantial effects on lipids.
BMI Is a Causal Risk Factor for COVID-19 Susceptibility, Severity
Massachusetts General Hospital researchers tested 17 cardiometabolic diseases and traits and found that body mass index was causally associated with developing COVID-19 and being hospitalized for the disease.