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Advances in Motion provides health care professionals with information about the latest breakthroughs, research and clinical advances from Massachusetts General Hospital.

Featured In Research and Innovation

A team of researchers led by Massachusetts General Hospital found that high dose inhaled nitric oxide gas safely improved oxygenation and reduced hospital lengths of stay for pregnant patients hospitalized with severe COVID-19 pneumonia.

Featured In Geriatrics and Palliative Care

As older patients in minority populations can be particularly disadvantaged in healthcare, the Disparities Research Unit at Massachusetts General Hospital is working to generate research that reduces these disparities. Unit Chief Margarita Alegría, PhD, discusses how her team improves care for these populations.

Featured In Neuroscience

New immunotherapy for brain cancer tackles the barrier of tumor heterogeneity using a home-grown combination of CAR T-cell therapy and bispecific antibodies.

Featured In Digestive Health

Researchers at the Massachusetts General Hospital Alcohol Liver Center found that substance use disorder, especially opioid use disorder, is a key modifiable risk factor for alcohol-associated liver disease in patients with alcohol use disorder.

Featured In Cardiovascular

Aneesh Bapat, MD, David Milan, MD, Saumya Das, MD, PhD, and colleagues demonstrated in a mouse model that genetic inhibition of serum glucocorticoid kinase 1 (SGK1) prevents some of the atrial fibrillation risk associated with diet-induced obesity, suggesting SGK1 is an attractive potential therapeutic target.

The Latest Orthopaedic Advances

The radiographic midpoint of the medial patellofemoral complex attachment on the femur is commonly used to guide femoral tunnel placement during reconstruction. Still, Mass General researchers found the radiographic locations of the most proximal and most distal fibers can significantly differ from that landmark.

Young-Min Kwon, MD, PhD, and colleagues in the Bioengineering Laboratory developed and validated a convolutional neural network that is 96% accurate or more when identifying arthroplasty implants from plain radiographs, whether primary or revision and whether implanted in the hip or knee.

Contributing Physicians

Chief, Center for Hip & Knee Replacement, Department of Orthopaedic Surgery, Massachusetts General Hospital, Director, MGH/NWH Kaplan Joint Center at NWH, Associate Professor of Orthopaedic Surgery, Harvard Medical School

Sports Medicine Orthopaedic Surgeon, Director, Women's Sports Medicine Program

Advances Specialties


Using the same approach as in a phenome-wide association study, Yen-Chen A. Feng, ScD, Jordan W. Smoller, MD, ScD, and colleagues systematically evaluated data on 15,181 individuals and did not identify any psychiatric manifestations of rare variations in medically actionable genes.


Massachusetts General Hospital clinician-researchers work to define which patients can benefit most from advanced proton therapy for cancer.


Based on a systematic review, Mass Eye and Ear otolaryngologists determined only 3% of the top U.S. commercial insurance companies provide coverage for gender-affirming voice therapy/voice surgery, and only 18% cover facial feminization surgery, despite the established medical benefits of these procedures.

Education & Training Opportunities

October 12-14, 2022

Led by faculty from the Corrigan Minehan Heart Center at Massachusetts General Hospital, this CME course provides a comprehensive review of state-of-the-art practices to diagnose and treat patients with cardiovascular conditions. It ensures attendees are current with advances in clinical cardiology and how to incorporate them into daily practice to optimize patient outcomes.

December 2, 2022

Co-directed by Massachusetts General Hospital leading experts, this one-day live virtual CME course on December 2, 2022, provides the fundamentals of diagnosis and treatment for aortic aneurysms, chronic aortic disease, aortic dissection, and other acute aortic syndromes. The comprehensive sessions will cover patient risk factors, evaluation, imaging, and current approaches for initial management and long-term follow-up of patients with aortic disease.

Clinical Trials

In Neuroscience

The study involves multiple visits over 6 months. You will complete an 8-week stress reduction treatment that includes a medical device worn in the ear and attend MRI and PET scans. You will also complete daily migraine diaries online.

In Cardiovascular

We are seeking individuals who self-identify as having high stress to participate in a randomized study using a mindfulness-based, stress-reduction intervention and PET-MR imaging.