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Advances in Motion provides health care professionals with information about the latest breakthroughs, research and clinical advances from Massachusetts General Hospital.

Featured In Neuroscience

Drug repurposing in Alzheimer's disease (DRIAD), a machine learning framework developed at Massachusetts General Hospital, screens currently available drugs that might serve as treatments for Alzheimer's disease—and examines unexplored targets for therapy.

Featured In Research and Innovation

Lael M. Yonker, MD, of the Department of Pediatrics; Galit Alter, PhD, core member of the Ragon Institute of Mass General, MIT and Harvard; and colleagues have uncovered an unexpected pathological role for IgA and monocyte-activating IgG antibodies in severe COVID-19 and severe MIS-C, respectively.

Featured In Digestive Health

By analyzing a large prospective cohort of women, Long H. Nguyen, MD, MS, and Andrew T. Chan, MD, MPH, of the Clinical and Translational Epidemiology Unit and the Division of Gastroenterology, and colleagues found that antibiotic use in mid- and late-adulthood, and recent antibiotic use regardless of age, were associated with subsequent development of diverticulitis.

Featured In Orthopaedics

With judicious patient selection, early definitive fixation of closed pilon fractures does not increase the risk of postoperative infection or wound complications that require surgical management, according to a retrospective study at three Harvard teaching hospital trauma centers.

Featured In Oncology

Esther Rheinbay, PhD and Gad Getz, PhD, of the Center for Cancer Research, and colleagues found that despite the use of novel, comprehensive strategies for discovery, point mutations that drive cancer were infrequent in noncoding genomic elements.

The Latest Cardiovascular Advances

Júlia Karády, MD, and Udo Hoffman, MD, MPH, of the Cardiovascular Imaging Research Center, observed marked discordance between high-sensitivity cardiac troponin assays that would lead to different management of patients with suspected acute coronary syndrome who had an inconclusive initial evaluation.

Radiologists may be called on to examine people suspected of concealing drugs in the GI tract, rectum or vagina. Rhea Malhotra, MD, and Ajay Singh, MD, MBBS, of the Department of Radiology, review approaches for protecting these individuals from complications and preventing the release of contraband into the community.

Contributing Physicians

Co-Director, Cardiac MR PET CT Program

Dr. Tawakol

Section Head, Heart Failure, Director, Cardiopulmonary Exercise Testing Laboratory, Medical Director, Cardiology ICU and Mechanical Circulatory Support Program

Advances Specialties

Geriatrics and Palliative Care

By analyzing a large prospective cohort of women, Long H. Nguyen, MD, MS, and Andrew T. Chan, MD, MPH, of the Clinical and Translational Epidemiology Unit and the Division of Gastroenterology, and colleagues found that antibiotic use in mid- and late-adulthood, and recent antibiotic use regardless of age, were associated with subsequent development of diverticulitis.

OB/GYN

Providing reassurance during the COVID-19 pandemic, Massachusetts General Hospital Fertility Center researchers found that neither home collection of semen samples nor delayed processing was negatively associated with sperm parameters or early outcomes of in vitro fertilization or intracytoplasmic sperm injection.

Rheumatology

Hyon K. Choi, MD, of the Division of Rheumatology, Allergy and Immunology, and colleagues report preliminary evidence that a dietitian-directed, DASH-patterned behavioral intervention lowers serum urate in gout patients not on urate-lowering drugs.

Education & Training Opportunities

June 16, 2021 - July 14, 2021

The Massachusetts General Hospital Corrigan Minehan Heart Center prepares future health care professionals and trains providers in innovative therapies and care. As part of these efforts, the center hosts regular Grand Rounds presentations from thought leaders and researchers on important cardiology topics. Cardiology Grand Rounds is open to all healthcare professionals.

June 4, 2021

The Practical Neurological Toolkit: High Yield Updates for the Office and the Ward is a one-day program to be hosted virtually on June 4, 2021. The content is focused on common and hot topics in neuroscience, as well as identified clinical growth areas for the field. The course targets non-neurologists, from backgrounds of primary care and internal medicine and including hospitalists, nurse practitioners, and other advanced practice providers and nurses.

Clinical Trials

In Neuroscience

The study involves brain imaging including fMRI and PET-MR, an 8-week stress reduction intervention, and at-home practice. You will also complete daily migraine diaries.

In Neuroscience

Do you think about your appearance nonstop or find yourself stuck in front of the mirror? You may be eligible to participate in a smartphone study on day-to-day factors that contribute to distress in body dysmorphic disorder (BDD).