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Featured
Brain Infusion of Genetically Modified Poliovirus Is Used to Treat Glioblastoma
A phase II trial kicked off at Massachusetts General Hospital involving multiple departments and research institutes are utilizing oncolytic viruses to treat glioblastomas.
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Featured
Combined Blockade of ATR and PARP Effective Against Glioblastoma in Mice
The combination of olaparib and an ATR inhibitor was effective against glioblastoma in mice, providing a much-needed therapeutic breakthrough for this deadly disease.
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Featured
Adding an NAMPT Inhibitor to Temozolomide Might Boost Its Effect in IDH-Mutant Glioma
IDH1/2-mutant glioma is often treated with temozolomide, but most of these cancers recur. Research at Massachusetts General Hospital suggests that combining the drug with an NAMPT inhibitor may improve its anticancer effect.
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Circulating Blood Counts Predict Response, Survival in Recurrent Glioblastoma Treated with Bevacizumab
Massachusetts General Hospital researchers are the first to report that changes in eosinophil, lymphocyte and platelet counts might serve as biomarkers of clinical outcomes in patients with recurrent glioblastoma who are treated with bevacizumab.
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Novel Combination Therapy Highly Effective Against IDH-mutant Glioma
Adding a poly(ADP-ribose) glycohydrolase inhibitor to temozolomide was highly effective in glioma cell lines and an IDH-mutant xenograft mouse model.
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Tumor Suppressor Gene PBRM1 Frequently Inactivated in Papillary Meningioma
The discovery of a frequent PBRM1 mutation in papillary meningioma suggests a potential new approach to developing therapies for this malignant, aggressive tumor.
Learn About the Stephen E. and Catherine Pappas Center for Neuro-Oncology
Neuro-Oncology contributors
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Bakhos A. Tannous, PhD
Associate Neuroscientist, Massachusetts General Hospital, Director, Vector Production and Development Core, Associate Professor, Harvard Medical School
Recent Article
Noninvasive Techniques in Brain Tumor Treatment -
Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Gene Fusions Detected in Plasma of Glioblastoma Patients, Suggesting New Approach to Liquid Biopsy
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Daniel P. Cahill, MD, PhD
Neurosurgeon
Recent Article
Novel Combination Therapy Highly Effective Against IDH-mutant Glioma
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Shannon Stott, PhD
Assistant Professor of Medicine, Department of Medicine, Harvard Medical School, Assistant in Genetics, Massachusetts General Hospital
Recent Article
How Liquid Biopsies Can Improve Brain Tumor Diagnoses
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William T. Curry, MD
Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology
Recent Article
Endonasal Surgery Using High-Speed Drill Puts Health Care Team at Risk of COVID-19
Stephen E. and Catherine Pappas Center for Neuro-Oncology at Mass General
The Stephen E. and Catherine Pappas Center for Neuro-Oncology offers the most advanced care for patients with brain tumors and nervous system tumors.
