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Featured
Brain Infusion of Genetically Modified Poliovirus Is Used to Treat Glioblastoma
A phase II trial kicked off at Massachusetts General Hospital involving multiple departments and research institutes are utilizing oncolytic viruses to treat glioblastomas.
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Featured
Combined Blockade of ATR and PARP Effective Against Glioblastoma in Mice
The combination of olaparib and an ATR inhibitor was effective against glioblastoma in mice, providing a much-needed therapeutic breakthrough for this deadly disease.
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Featured
Adding an NAMPT Inhibitor to Temozolomide Might Boost Its Effect in IDH-Mutant Glioma
IDH1/2-mutant glioma is often treated with temozolomide, but most of these cancers recur. Research at Massachusetts General Hospital suggests that combining the drug with an NAMPT inhibitor may improve its anticancer effect.
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Review: Glioblastoma and Astrocytes Interactions, Mediated by Extracellular Vesicles, Affects Tumor Progression
A review by Xandra O. Breakefield, PhD and colleagues explains how extracellular vesicle–directed communication between glioblastoma cells and astrocytes changes astrocytes from protecting neurons to promoting tumor growth, migration and invasiveness.
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Local NAMPT Inhibition Enhances Checkpoint Immunotherapy for Glioblastoma
In a mouse model of glioblastoma, sequential therapy with a nicotinamide phosphoribosyltransferase inhibitor, delivered locally via polymer microparticles, and an immune checkpoint inhibitor improved survival over either agent used as monotherapy.
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Categories of Genomic Profiles of Aggressive Meningiomas to Facilitate Drug Development
Massachusetts General Hospital researchers conducted the largest-yet genomic profiling study of high-grade/progressive meningiomas and detected three distinct patterns that have clinical implications.
Learn About the Stephen E. and Catherine Pappas Center for Neuro-Oncology
Neuro-Oncology contributors
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Bakhos A. Tannous, PhD
Associate Neuroscientist, Massachusetts General Hospital, Director, Vector Production and Development Core, Associate Professor, Harvard Medical School
Recent Article
Noninvasive Techniques in Brain Tumor Treatment -
Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Partnering to Treat Acoustic Neuroma
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Daniel P. Cahill, MD, PhD
Neurosurgeon, Massachusetts General Hospital, Neurosurgical Oncologist, Mass General Cancer Center
Recent Article
Local NAMPT Inhibition Enhances Checkpoint Immunotherapy for Glioblastoma
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Shannon Stott, PhD
Assistant Professor of Medicine, Department of Medicine, Harvard Medical School, Assistant in Genetics, Massachusetts General Hospital
Recent Article
How Liquid Biopsies Can Improve Brain Tumor Diagnoses
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William T. Curry, MD
Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology
Recent Article
Endonasal Surgery Using High-Speed Drill Puts Health Care Team at Risk of COVID-19
Stephen E. and Catherine Pappas Center for Neuro-Oncology at Mass General
The Stephen E. and Catherine Pappas Center for Neuro-Oncology offers the most advanced care for patients with brain tumors and nervous system tumors.
