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Featured
New Targeted Glioma Therapy Could Suppress Tumor Growth
Mass General has developed a genotype-targeted therapy for glioma, designed to be given at the tumor site during surgery, and an accompanying rapid diagnostic.
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Featured
Surviving Gliomas Through Antibodies and Vaccination
Immunotherapy for glioma is under active investigation, but tumor-associated immunosuppression is a major obstacle. A Mass General team studied an investigational monoclonal antibody in mice with glioma, alone and in combination with tumor cell vaccination.
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Featured
How Liquid Biopsy Could Improve Brain Tumor Treatment and Diagnoses
Mass General doctors are developing a liquid biopsy for brain tumors to reduce the need for invasive tissue biopsies.
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Third-Generation CAR T-cell Therapy for Glioblastoma Is Effective in Animal Model
A new chimeric antigen receptor T-cell strategy for glioblastoma, developed at Massachusetts General Hospital and proven effective in mice, relies on co-culturing the T cells with artificial antigen-presenting cells that express co-stimulatory molecules, to boost T-cell activation and persistence.
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Researchers Are Studying the Origin of Glioma
Neuro-oncologists at Massachusetts General Hospital are working toward a better understanding of gliomagenesis as a basis for the development of therapies, as well as identification of biomarkers to stratify patients for personalized treatment.
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Adding an NAMPT Inhibitor to Temozolomide Might Boost Its Effect in IDH-Mutant Glioma
IDH1/2-mutant glioma is often treated with temozolomide, but most of these cancers recur. Research at Massachusetts General Hospital suggests that combining the drug with an NAMPT inhibitor may improve its anticancer effect.
Brain Tumor contributors
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Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Third-Generation CAR T-cell Therapy for Glioblastoma Is Effective in Animal Model
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Brian V. Nahed, MD, MSc
Neurosurgical Oncology / Brain Tumor Surgeon / Mass General Brain Tumor Center, Neurosurgical Spinal Disorders, Associate Professor, Harvard Medical School
Associate Director Mass General Neurosurgery ProgramRecent Article
The Mass General Neurosurgery Mission
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William T. Curry, MD
Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology
Recent Article
Triple Immunotherapy Completely Eradicates Glioma in Animal Models
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.Resource Links
