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Featured
New Targeted Glioma Therapy Could Suppress Tumor Growth
Mass General has developed a genotype-targeted therapy for glioma, designed to be given at the tumor site during surgery, and an accompanying rapid diagnostic.
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Featured
Surviving Gliomas Through Antibodies and Vaccination
Immunotherapy for glioma is under active investigation, but tumor-associated immunosuppression is a major obstacle. A Mass General team studied an investigational monoclonal antibody in mice with glioma, alone and in combination with tumor cell vaccination.
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Featured
How Liquid Biopsy Could Improve Brain Tumor Treatment and Diagnoses
Mass General doctors are developing a liquid biopsy for brain tumors to reduce the need for invasive tissue biopsies.
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Novel Tandem CAR T-Cell Effective Against Heterogeneous Glioblastoma
Massachusetts General Hospital researchers have developed TanCART, the first chimeric antigen receptor T cell that targets EGFRvIII and IL-13R?2 simultaneously, and found it was effective in vitro and in murine models of heterogeneous glioblastoma, including patient-derived xenografts.
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Targeting Lipid Synthesis Efficacious in Glioblastoma Mouse Models
Katharina M. Eyme, Alessandro Sammarco, PhD, Christian E. Badr, PhD, and colleagues found YTX-7739, an orally available stearoyl coenzyme A desaturase 1 inhibitor, triggered lipotoxicity in glioblastoma stem-like cells, and with or without temozolomide, it was efficacious in mouse models of glioblastoma.
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Designing Leading-Edge Immunotherapy for Brain Cancer
New immunotherapy for brain cancer tackles the barrier of tumor heterogeneity using a home-grown combination of CAR T-cell therapy and bispecific antibodies.
Brain Tumor Contributors
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Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease
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Brian V. Nahed, MD, MSc
Neurosurgical Oncology / Brain Tumor Surgeon / Mass General Brain Tumor Center, Neurosurgical Spinal Disorders, Associate Professor, Harvard Medical School
Director, Mass General Neurosurgery Residency ProgramRecent Article
Cadaver-free Simulation Model Feasible for Improving Residents' Craniotomy Skills
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Daniel P. Cahill, MD, PhD
Neurosurgeon, Massachusetts General Hospital, Neurosurgical Oncologist, Mass General Cancer Center
Recent Article
Palbociclib Demonstrates Activity Against Progressive Brain Metastases Harboring CDK Pathway Alterations
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William T. Curry, MD
Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology, Massachusetts General Hospital, Adeline Rose Wydotis Professor of Neurosurgery, Harvard Medical School
Recent Article
Novel Tandem CAR T-Cell Effective Against Heterogeneous Glioblastoma
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.