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Featured
New Targeted Glioma Therapy Could Suppress Tumor Growth
Mass General has developed a genotype-targeted therapy for glioma, designed to be given at the tumor site during surgery, and an accompanying rapid diagnostic.
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Featured
Surviving Gliomas Through Antibodies and Vaccination
Immunotherapy for glioma is under active investigation, but tumor-associated immunosuppression is a major obstacle. A Mass General team studied an investigational monoclonal antibody in mice with glioma, alone and in combination with tumor cell vaccination.
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Featured
How Liquid Biopsy Could Improve Brain Tumor Treatment and Diagnoses
Mass General doctors are developing a liquid biopsy for brain tumors to reduce the need for invasive tissue biopsies.
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Case Series: Intraventricular Infusion of Dual-targeting CAR T-Cells for Glioblastoma
Massachusetts General Hospital researchers showed rapid, dramatic radiographic responses in three patients with glioblastoma who received intraventricular infusion of CAR T-cells that targeted both EGFR variant III and wild-type EGFR. In two of the patients, however, the effects were transient.
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Review: Cognitive Issues in Patients With IDH-mutant Gliomas
Michael W. Parsons, PhD, and David S. Sabsevitz, PhD, recently shared their expertise about how and why to integrate neuropsychological assessment into the preoperative care and long-term follow-up of patients with IDH-mutant glioma.
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Review: The Role of Antibody-Based Therapies in Neuro-Oncology
Rishab Ramapriyan, William T. Curry, MD, Bryan D. Choi, MD, PhD, and colleagues describe the antibody-based therapies being used to treat glioblastoma and other central nervous system tumors, with special attention to the challenges of blood–brain barrier penetration and tumor-derived immunosuppression.
Brain Tumor Contributors
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Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease
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Brian V. Nahed, MD, MSc
Neurosurgical Oncology / Brain Tumor Surgeon / Mass General Brain Tumor Center, Neurosurgical Spinal Disorders, Associate Professor, Harvard Medical School
Director, Mass General Neurosurgery Residency ProgramRecent Article
Cadaver-free Simulation Model Feasible for Improving Residents' Craniotomy Skills
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Daniel P. Cahill, MD, PhD
Neurosurgeon, Massachusetts General Hospital, Neurosurgical Oncologist, Mass General Cancer Center
Recent Article
Rare IDH2-mutant Glioma Shares Common Molecular Targets With IDH1-mutant Glioma
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William T. Curry, MD
Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology, Massachusetts General Hospital, Adeline Rose Wydotis Professor of Neurosurgery, Harvard Medical School
Recent Article
Review: The Role of Antibody-Based Therapies in Neuro-Oncology
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.