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Featured
Review: Pathways of Colorectal Carcinogenesis
Dozens of different somatic mutations have been identified in colorectal tumors, but colorectal cancer appears to develop via one of only a few distinct pathways.
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Featured
Review: Lifestyle Factors, Changes in Gut Microbiota Are Linked in Development of Colorectal Cancer
Both diet, lifestyle and the gut microbiome have been implicated in colorectal tumorigenesis. Accumulating evidence suggests these two influences are related and may point the way to better prevention strategies.
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Featured
Fiber Intake Has Survival Benefit in Patients Already Diagnosed with Colorectal Cancer
In the first prospective study of the topic, gastroenterologists and epidemiologists at Massachusetts General Hospital found that higher fiber intake after a diagnosis of nonmetastatic colorectal cancer is associated with longer survival.
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Taking Aspirin Associated With Reduction in Colorectal Cancer Among High-Risk Population
Massachusetts General Hospital researchers found that regular aspirin use was associated with the greatest reduction of colorectal cancer among those at the highest risk.
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Post-Diagnosis Multivitamin Supplementation May Prolong Survival Among Patients With Nonmetastatic CRC
Mingyang Song, MBBS, ScD, and colleagues present evidence that the benefit of multivitamin supplements may extend beyond primary prevention of colorectal cancer (CRC). They linked the use of three to five multivitamin tablets/week after diagnosis of nonmetastatic CRC to lower CRC-specific and overall mortality.
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Vitamin C Might Have Clinical Benefit Against KRAS- and BRAF-mutated CRC
Shuji Ogino, MD, PhD, Mingyang Song, MBBS, ScD, and colleagues leveraged data from two large, prospective U.S. studies that showed the use of vitamin C after diagnosis of colorectal cancer with KRAS or BRAF mutations was associated with a 26% reduction in the risk of disease-specific mortality.
Colorectal Cancer Contributors
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Daniel C. Chung, MD
Medical Co-Director, Center for Cancer Risk Assessment, Director, High-Risk GI Cancer Clinic, Mass General Brigham Cancer Institute, Professor of Medicine, Harvard Medical School
Recent Article
Pilot Study: Virtual Reality Is a Feasible Alternative to Narcotics During Colonoscopy
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David L. Berger, MD
Colorectal and Gastrointestinal Surgeon, Division of Gastrointestinal & Oncologic Surgery, Mass General, Associate Professor of Surgery, Harvard Medical School
Recent Article
Likelihood of Death at Home Is Improving in Colorectal Cancer, but Sociodemographic Disparities Persist
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Hiroko Kunitake, MD, MPH
Gastrointestinal and Colorectal Surgeon, Surgical Director, Perioperative Optimization of Senior Health (POSH) Clinic, Massachusetts General Hospital, Assistant Professor of Surgery, Harvard Medical School
Recent Article
New Multidisciplinary Clinic Aims to Improve Surgical Outcomes in Older Adults -
Liliana G. Bordeianou, MD, MPH, FACS, FASCRS
Site Director of the Colorectal Surgery Program, Co-Director, Pelvic Floor Disorders Center, Mass General, Co-Chair, Mass General Brigham Colorectal Surgery Collaborative, Professor of Surgery, Harvard Medical School
Recent Article
Evaluating Cell Therapy as a Therapeutic Option for Chronic Fecal Incontinence
Mass General Brigham Cancer Institute
Mass General Brigham Cancer Institute unites leading experts and resources across our academic medical centers, making it one of the nation’s top providers of cancer care.