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Featured
Review: Pathways of Colorectal Carcinogenesis
Dozens of different somatic mutations have been identified in colorectal tumors, but colorectal cancer appears to develop via one of only a few distinct pathways.
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Featured
Review: Lifestyle Factors, Changes in Gut Microbiota Are Linked in Development of Colorectal Cancer
Both diet, lifestyle and the gut microbiome have been implicated in colorectal tumorigenesis. Accumulating evidence suggests these two influences are related and may point the way to better prevention strategies.
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Featured
Fiber Intake Has Survival Benefit in Patients Already Diagnosed with Colorectal Cancer
In the first prospective study of the topic, gastroenterologists and epidemiologists at Massachusetts General Hospital found that higher fiber intake after a diagnosis of nonmetastatic colorectal cancer is associated with longer survival.
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Size of Largest Colorectal Liver Metastasis is an Independent Prognostic Factor After Neoadjuvant Therapy
In patients with colorectal cancer metastasis confined to the liver, Motaz Qadan, MD, PhD, of the Department of Surgery, found that larger metastases predict poorer disease-free and disease-specific survival after neoadjuvant chemotherapy and liver resection.
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Changes in DNA Structure with Aging Restrain Progression of Cancer
The DNA structure of normal cells breaks down as they age—but that can help prevent the development of cancer. Broadly speaking, the human genome is divided into an open, transcriptionally active inner layer of DNA (compartment A), where the genes most often used by cells are readily accessible, and a relatively...
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Anatomic Classification of Colorectal Cancer Is Too Broad for Accurate Risk Prediction
Risk factor profiles for colorectal cancer differ when the proximal colon, distal colon and rectum are reclassified as seven distinct sites.
Mass General Cancer Center Contributors
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Daniel C. Chung, MD
Clinical Chief, Gastrointestinal Unit, Director, High-Risk GI Cancer Clinic
Recent Article
Pilot Study: Virtual Reality Is a Feasible Alternative to Narcotics During Colonoscopy
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David L. Berger, MD
Colorectal and Gastrointestinal Surgeon, Massachusetts General Hospital Division of General Surgery, Associate Professor of Surgery, Harvard Medical School
Recent Article
Primary Tumor Resection Improves Survival in Advanced Colorectal Cancer
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Hiroko Kunitake, MD
Colorectal Surgeon, Center for Pelvic Floor Disorders, Massachusetts General Hospital, Assistant Professor of Surgery, Harvard Medical School
Recent Article
New Research Further Quantifies Benefits of Preventative Colonoscopy Screening -
Liliana G. Bordeianou, MD, MPH, FACS, FASCRS
Director, Pelvic Floor Disorders Center, Massachusetts General Hospital, Professor and Site Director, Mass General Colorectal Surgery, Harvard Medical School
Recent Article
Patient-Driven Consensus Effort Defines Ileoanal Pouch Syndrome
Mass General Cancer Center
An integral part of one of the world’s most distinguished academic medical centers, the Massachusetts General Hospital Cancer Center is among the leading cancer care providers in the United States.
