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Featured
Is Accelerated Infliximab Induction Beneficial for Severe Ulcerative Colitis?
While short-interval administration of infliximab was equally efficacious as standard administration for severe ulcerative colitis, a multicenter retrospective study has shown that a higher dose upon initiation reduced the risk of colectomy.
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Featured
Discovering the Role of C1orf106 in Patients with IBD
C1orf106 is a known susceptibility gene for inflammatory bowel disease, and now Massachusetts General researchers have identified its role: it "fine tunes" the integrity of the intestinal epithelial barrier.
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Featured
Obesity Tied to Risk of Diverticulosis
By analyzing a cohort of adults who underwent colonoscopy, gastroenterologists at Massachusetts General Hospital have determined that overweight and obesity substantially increase the risk of diverticulosis.
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Newly Identified Metabolic Targets May Improve Treatment of C. difficile
Leo L. Cheng, PhD, Lynn Bry, MD, PhD, and colleagues used live-cell high-resolution magic angle spinning 13-carbon–labeled nuclear magnetic resonance spectroscopy to investigate dynamic anaerobe metabolism. Their findings identify new preventive and therapeutic strategies to counter Clostridioides difficile infections.
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Single-Cell Map of Crohn's Disease Provides New Directions for Drug Development
Ramnik J. Xavier, MD, PhD, Lingjia Kong, PhD, and colleagues have produced the largest single-cell resource for studying Crohn's disease. This atlas provides unprecedented detail about cellular and transcriptomic changes that are distinct between the small and large intestines.
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Role of Biomarkers in Ulcerative Colitis Management
Ashwin N. Ananthakrishnan, MBBS, MPH, and colleagues were part of an American Gastroenterological Association panel that recommended how to use three biomarkers—serum C-reactive protein, fecal calprotectin, and fecal lactoferrin—in place of endoscopic assessment of ulcerative colitis.
Bowel Disease Contributors
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Andrew T. Chan, MD, MPH
Daniel K. Podolsky Professor of Medicine, Harvard Medical School, Director for Cancer Epidemiology, Mass General Cancer Center, Chief, Clinical and Translational Epidemiology Unit, Department of Medicine
Recent Article
Maternal Consumption of Ultra-processed Foods Linked to Weight Gain in Offspring
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Ashwin N. Ananthakrishnan, MBBS, MPH
Director of the Crohn's and Colitis Center, Division of Gastroenterology, Mass General, Associate Professor of Medicine, Harvard Medical School
Recent Article
Role of Biomarkers in Ulcerative Colitis Management
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Hamed Khalili, MD, MPH
Gastroenterologist, Clinical and Translational Epidemiology Unit, Director of Clinical Research in Inflammatory Bowel Disease in the Division of Gastroenterology, Associate Professor of Medicine, Harvard Medical School
Recent Article
Initiating Oral Contraception Does Not Change Gut Microbiome in Healthy Women
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Wenjie Ma, MBBS, ScD
Instructor and Investigator in the Clinical and Translational Epidemiology Unit, Assistant in Epidemiology in the Division of Gastroenterology, Instructor in Medicine, Harvard Medical School
Recent Article
Initiating Screening Before Age 50 Reduces Risk of Colorectal Cancer
Digestive Healthcare at Mass General
The Massachusetts General Hospital Digestive Healthcare Center is a collaborative practice of gastroenterologists, endoscopists, surgeons, radiologists, pathologists, hepatologists, oncologists and radiation oncologists dedicated to the prevention, diagnosis, treatment and management of digestive diseases.