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Featured
Is Accelerated Infliximab Induction Beneficial for Severe Ulcerative Colitis?
While short-interval administration of infliximab was equally efficacious as standard administration for severe ulcerative colitis, a multicenter retrospective study has shown that a higher dose upon initiation reduced the risk of colectomy.
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Featured
Discovering the Role of C1orf106 in Patients with IBD
C1orf106 is a known susceptibility gene for inflammatory bowel disease, and now Massachusetts General researchers have identified its role: it "fine tunes" the integrity of the intestinal epithelial barrier.
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Featured
Obesity Tied to Risk of Diverticulosis
By analyzing a cohort of adults who underwent colonoscopy, gastroenterologists at Massachusetts General Hospital have determined that overweight and obesity substantially increase the risk of diverticulosis.
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New Scoring System Allows Assessment of the Severity of Ileoanal Pouch Syndrome
Paul Cavallaro, MD, Liliana Bordeianou, MD, MPH, and colleagues developed the ileoanal pouch syndrome (IPS) severity score, which is unique among postoperative bowel function scores in that it was entirely developed in a population of patients with pouches and items weighted differently based on patient input.
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Novel Therapeutic Strategy Identified for Crohn's Disease
Hajera Amatullah, PhD, Kate L. Jeffrey, PhD, and colleagues determined that loss of speckled protein 140 (SP140), a chromatin reader, results in uncontrolled topoisomerase activity. They recommend investigating topoisomerase inhibitors for the treatment of Crohn's disease in patients with SP140 mutations.
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Consensus Statement: Lifestyle and Behavior Modification for Management of IBD
Ashwin N. Ananthakrishnan, MBBS, MPH, director of the Crohn's and Colitis Center, helped direct the International Organization for the Study of Inflammatory Bowel Diseases (IBD) in issuing guidance about the role of lifestyle and behavior modification in managing Crohn's disease and ulcerative colitis.
Bowel Disease Contributors
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Andrew T. Chan, MD, MPH
Daniel K. Podolsky Professor of Medicine, Harvard Medical School, Director for Cancer Epidemiology, Mass General Cancer Center, Chief, Clinical and Translational Epidemiology Unit, Department of Medicine
Recent Article
Maternal Consumption of Ultra-processed Foods Linked to Weight Gain in Offspring
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Ashwin N. Ananthakrishnan, MBBS, MPH
Director of the Crohn's and Colitis Center, Division of Gastroenterology, Mass General, Associate Professor of Medicine, Harvard Medical School
Recent Article
Consensus Statement: Lifestyle and Behavior Modification for Management of IBD
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Hamed Khalili, MD, MPH
Gastroenterologist, Clinical and Translational Epidemiology Unit, Director of Clinical Research in Inflammatory Bowel Disease in the Division of Gastroenterology, Associate Professor of Medicine, Harvard Medical School
Recent Article
Initiating Oral Contraception Does Not Change Gut Microbiome in Healthy Women
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Wenjie Ma, MBBS, ScD
Instructor and Investigator in the Clinical and Translational Epidemiology Unit, Assistant in Epidemiology in the Division of Gastroenterology, Instructor in Medicine, Harvard Medical School
Recent Article
Initiating Screening Before Age 50 Reduces Risk of Colorectal Cancer
Digestive Healthcare at Mass General
The Massachusetts General Hospital Digestive Healthcare Center is a collaborative practice of gastroenterologists, endoscopists, surgeons, radiologists, pathologists, hepatologists, oncologists and radiation oncologists dedicated to the prevention, diagnosis, treatment and management of digestive diseases.