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Featured
Functional MRI Shows Promise for Studying Psychotic Experiences, Testing Treatment
People with schizophrenia are known to have hippocampal overactivity. Is the same true of people with subthreshold psychosis, and are there clinical implications?
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Featured
Prenatal Folic Acid and Schizophrenia Prevention
Joshua Roffman, MD, MMSc, discusses his recent work investigating folic acid’s potential neuroprotective effects that may guard against schizophrenia development.
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Featured
Prenatal Exposure to Folic Acid-fortified Foods May Reduce Mental Illness Risk
Fortification of grain-based foods with folic acid, a practice instituted in the U.S. in the 1990s to prevent neural tube defects in infants, may also reduce the incidence of severe mental illnesses like schizophrenia that initially appear in young adulthood.
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Sex-specific Genetic Effects Across Neuropsychiatric and Behavioral Traits Identified for the First Time
Jill M. Goldstein, PhD, and Jordan W. Smoller, MD, ScD, of the Department of Psychiatry, and colleagues have reported the first modest evidence of sex-dependent autosomal genetic effects across neuropsychiatric and behavioral traits.
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Synaptic Pruning May Play a Role in the Development and Treatment of Schizophrenia
New research suggests a link between excessive synaptic pruning in human cells and schizophrenia—a major step towards disease prevention.
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Prenatal Folic Acid Exposure Linked to Reduced Risk of Psychosis in Adolescence
Psychiatrists at Massachusetts General Hospital present the first evidence that prenatal exposure to folic acid has a beneficial effect on postnatal brain development—and reduces the risk of psychotic disorders later in life.
Schizophrenia Contributors
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Daphne J. Holt, MD, PhD
Co-director, Schizophrenia Clinical and Research Program, Director, Emotion and Social Neuroscience Laboratory; Director, Resilience Program , MGH Research Scholar 2018-2023
Recent Article
Uncovering the Relationship Between Loneliness and Poor Health Outcomes
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Joshua L. Roffman, MD, MMSc
Director of the Mass General Early Brain Development Initiative
Recent Article
Genetic Patterning for Psychopathology Is Distinct in Children and Adults
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.