Posts by Daphne J. Holt, MD, PhD
-
Uncovering the Relationship Between Loneliness and Poor Health Outcomes
In an ongoing project, Mass General researchers are studying the epidemic of worsening loneliness and social isolation and its relationship to poor health outcomes. They have identified a potential marker of loneliness, which could help understand the effects of loneliness on the body and even how to reverse them.
-
Diminished Frontal Pole Size, Functional Connectivity Linked to Elevated Suicide Risk in Young Adults
Gwang-Won Kim, PhD, Maurizio Fava, MD, Daphne J. Holt, MD, PhD, and colleagues published evidence that reduced frontal pole size and reduced functional connectivity between the frontal pole and the inferior frontal cortex are markers of elevated suicidality in young adults.
-
Will Social Distancing Have a Lasting Impact on 'Personal Space'?
Researchers at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital are using virtual reality to study how 'personal space' requirements have changed as a result of social distancing during the COVID-19 pandemic—and the possible impact of these changes on social functioning.
-
Teaching Resiliency to Help Health Care Professionals Cope: Q&A with Daphne J. Holt, MD, PhD
In this Q&A, Daphne J. Holt, MD, PhD, teaches skills for dealing with the overwhelming stress on health care workers during the pandemic and discusses how learning resiliency through online training can help them manage their mental health during this stressful time.
-
Amygdala Dysregulation Is a Marker of Low Resilience and Risk of Depression in Young Adults
In nondepressed young adults who had a family history of depression, higher amygdala activity on functional MRI was significantly correlated with lower resilience.
-
Functional MRI Shows Promise for Studying Psychotic Experiences, Testing Treatment
People with schizophrenia are known to have hippocampal overactivity. Is the same true of people with subthreshold psychosis, and are there clinical implications?
Biography
Dr. Daphne J. Holt is an associate professor of Psychiatry at Harvard Medical School. She serves as director of the Emotion and Social Neuroscience Laboratory at Mass General, director of the Resilience Program and co-director of the Schizophrenia Clinical and Research Program.
Dr. Holt attended medical school at the University of Chicago Pritzker School of Medicine, where she also received a PhD in neurobiology. She received her training in psychiatry in the Mass General/McLean Hospital adult psychiatry residency program, becoming a faculty member of the Massachusetts General Hospital Psychiatry Department in 2004.
Dr. Holt’s research focuses on understanding the neural basis of emotional function and social behavior, and abnormalities in these domains in neuropsychiatric disorders such as schizophrenia. She is also beginning to identify changes in these systems in young people who are at risk for neuropsychiatric disorders, in an effort to develop methods to detect these changes before the onset of these illnesses. She also oversees a clinical program that focuses on reducing risk for neuropsychiatric illness.
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.