Advances in Motion provides health care professionals with information about the latest breakthroughs, research and clinical advances from Massachusetts General Hospital.
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Featured In Oncology
An Expert’s Perspective on What Daraxonrasib Means for the Future of Pancreatic Cancer Care
Phase 3 RASolute 302 data showed daraxonrasib doubled overall survival versus chemotherapy in previously treated metastatic pancreatic cancer. Mass General Brigham Cancer Institute is participating in the FDA-authorized expanded access program, with approximately 50 patients consented to date.
Featured In Urology
How a Neoadjuvant Microdevice Could Transform Treatment of Prostate Cancer
Mass General Brigham researchers are in the early stages of developing a 3mm implantable chip that delivers micro-doses of drugs directly into prostate tumors prior to planned radical prostatectomy. Analyzing tumor response eventually could help clinicians optimize drug selection for individual patients.
Featured In Neuroscience
Reimagining Neurologic Care Through Population Health Strategies
Two Mass General Brigham neurologists spent nearly a year examining how five esteemed academic health systems are using population health approaches to improve neurologic care. They are among the authors of a paper summarizing relevant case studies and lessons learned from their investigation.
Featured In OB/GYN
Neoadjuvant Chemotherapy for Advanced Ovarian Cancer Improves Short-term Survival Regardless of Hospital Case Volume
For patients with advanced ovarian cancer, high use of neoadjuvant chemotherapy improves 90-day surgical mortality at hospitals of all case volumes, but that outcome and 5-year survival are best for patients treated at high-volume centers with high use of neoadjuvant chemotherapy.
Featured In Radiology
Emerging Treatment Offers Hope for Patients with Chronic Musculoskeletal Pain
Could a minimally invasive procedure ease chronic musculoskeletal pain? Yan Epelboym, MD, MPH, discusses the promise of trans-arterial embolization.
The Latest Oncology Advances
Improving Prostate MRI Screening for Genetically High-Risk Individuals
New research with roots at Mass General Brigham Cancer Institute shows that combining age-adjusted PSA thresholds with upfront MRI improves detection of clinically significant prostate cancer in genetically high-risk men—outperforming either test alone.
Experimental Drug Shows Success in Targeting Key Pathway in Recurrent Ameloblastoma
After being diagnosed with an ameloblastoma in his right mandible at age 20, a patient had numerous surgical debulking and reconstructive procedures. When further surgery was no longer possible, he enrolled in a first-in-human trial of a drug that targets the Wnt/β-catenin pathway. The drug produced a dramatic radiographic response, including near resolution of several tumor masses and reduction in pressure on the brain.
Contributing Physicians
Genevieve M. Boland, MD, PhD
Vice Chair of Research, Department of Surgery, Massachusetts General Hospital, Section Head, Melanoma and Sarcoma Surgery Programs, Surgical Director, Termeer Center for Targeted Therapies, Mass General Brigham Cancer Institute
Marcela V. Maus, MD, PhD
Director, Cellular Immunotherapy Program, Mass General Brigham Cancer Institute, Associate Professor of Medicine, Harvard Medical School
Advances Specialties
Cardiovascular
Study Reveals Brain-Heart Connection in Depression and Anxiety
Investigators at Mass General Brigham found that stress-related brain activity may explain the increased risk of heart disease with depression and anxiety.
Neuroscience
Reimagining Neurologic Care Through Population Health Strategies
Two Mass General Brigham neurologists spent nearly a year examining how five esteemed academic health systems are using population health approaches to improve neurologic care. They are among the authors of a paper summarizing relevant case studies and lessons learned from their investigation.
Orthopaedics
Emerging Treatment Offers Hope for Patients with Chronic Musculoskeletal Pain
Could a minimally invasive procedure ease chronic musculoskeletal pain? Yan Epelboym, MD, MPH, discusses the promise of trans-arterial embolization.
May 9, 2025
Conference: Midlife Women's Health 2025: A Multidisciplinary Approach to Care
The Midlife Women's Health 2025 course is led by a multidisciplinary group of experts from Massachusetts General Hospital who will present on the evaluation and management of osteoporosis, gastrointestinal malignancy, stress, obesity, substance use disorder, anxiety, sexual dysfunction, breast cancer, and menopausal hormone therapy to assist clinicians in caring for their midlife patients.
Brain mechanisms of vagus nerve stimulation and stress reduction training for migraine
The study involves multiple visits over 6 months. You will complete an 8-week stress reduction treatment that includes a medical device worn in the ear and attend MRI and PET scans. You will also complete daily migraine diaries online.
Multimodal profiling of stress-induced immune reprogramming in cardiovascular participants
The purpose of this research study is to learn about the effects of stress on the brain and disease of the heart and blood vessels (cardiovascular disease or CVD).
