Posts by Zheng-Yi Chen, DPhil
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CRISPR-Cas9 Genome Editing Treats Genetic Hearing Loss by Promoting Outer Hair Cell Survival
Yong Tao, PhD, Veronica Lamas, PhD, and Zheng-Yi Chen, DPhil, have extended their previous murine research to show CRISPR-associated protein 9 (Cas9)-based genome editing can treat hearing loss associated with monogenic mutations in outer hair cell genes and digenic mutations affecting both inner and outer hair cells.
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Virally Mediated Gene Therapy Treats Genetic Hearing Loss in Aged Mouse Model
Zheng-Yi Chen, DPhil, and colleagues are the first to demonstrate rescue of genetic hearing loss with a gene therapy delivered by adeno-associated virus in an aged animal model. The study also serves as proof-of-principle that other gene therapies be developed for older adults.
Biography
Zheng-Yi Chen, DPhil, is an associate scientist at Mass Eye and Ear, and an associate professor of Otolaryngology–Head and Neck Surgery at Harvard Medical School.
Mass Eye and Ear/Mass General Otolaryngology–Head and Neck Surgery
A teaching hospital of Harvard Medical School, Mass Eye and Ear/Massachusetts General Hospital combines the expertise of highly specialized ear, nose, and throat physicians, audiologists, speech-language pathologists and auxiliary health care professionals to provide care for patients with problems affecting the ear, nose, throat, head and neck areas. The department, which is led by Chief and Chair Mark A. Varvares, MD, FACS, is one of the largest otolaryngology–head and neck surgery (OHNS) departments in the country, with more than 70 physicians staffed at 15 locations in the greater Boston area.
