Posts by Orhun K. Muratoglu, PhD
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First AI Model Developed for Diagnosis of Hip Dysplasia From Plain Radiographs
Martin Magnéli, MD, PhD, Orhun Muratoglu, PhD, and colleagues have developed two convolutional neural networks that can read plain radiographs and classify hips as dysplastic or non-dysplastic with 83% to 92% accuracy, and detect the severity of hip dysplasia based on the Crowe or Hartofilakidis classifications.
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Advances in Arthroplasty From the Harris Orthopaedics Lab: Maximizing Safety and Effectiveness
The Harris Orthopaedic Laboratory at Massachusetts General Hospital is driving research and innovation to eliminate infection and improve pain management related to total joint arthroplasty.
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Bone Penetration of Cement Does Not Differ by Cement Type or Application Timepoint
Orthopedics researchers at Massachusetts General Hospital used the first porcine model to study how cement bone penetration is influenced by cement type and application timing. They found no penetration advantage of any specific cement or timing, but it's best to apply cement early for optimal mantle thickness.
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Validating N95 Respirator Decontamination Methods
Massachusetts General Hospital investigators have confirmed the efficacy of hydrogen peroxide vapor as an effective N95 respirator decontamination method.
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Size of Adapter Sleeve in Revision Hip Arthroplasty Affects Fixation Strength
When ceramic modular heads are used in revision hip arthroplasty, impact force and the size of the titanium adapter sleeve influence the stability of the implant, according to the first study of the issue.
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Improvements in Outcomes for Total Joint Patients from the Harris Lab
In this video, Orhun Muratoglu, PhD, director of Harris Orthopaedics Laboratory at Massachusetts General Hospital, and Ebru Oral, PhD, associate director of biomaterials at Harris Orthopaedics Laboratory, discuss their work in improving outcomes in total joint patients.
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New Polymer for Joint Implants Retains Superior Toughness When Produced at Scale
A vitamin E–blended, peroxide cross-linked, high-temperature ultrahigh molecular weight polyethylene, created at Massachusetts General Hospital, is a promising material for manufacturing joint implant bearing surfaces due to a single-step consolidation/cross-linking process and resulting superior properties.
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Research Advances from Mass General Orthopaedics
Researchers from the Department of Orthopaedics discuss the clinical and translational work they are doing at Massachusetts General Hospital.
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VIDEO: Predictors of Periprosthetic Acetabular Radiolucency Progression in Metal on Metal Hips
In an interview with Healio, Orhun K. Muratoglu, PhD, Director of the Harris Orthopaedics Laboratory at Mass General, discusses the predictors of periprosthetic acetabular radiolucency progression in metal-on-metal (MoM) hip implants.
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Reducing Infection in Total Joint Replacements with Drug-Eluting Implants
Researchers at Massachusetts General Hospital have developed a promising new drug-eluting joint implant technology adding antibiotics to ultra-high molecular weight polyethylene (UHMWPE) material.
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Improving Reverse Total Shoulder Arthroplasty Performance with Highly Cross-linked Polyethylene Implants
For reverse shoulder total arthroplasty (rSTA) patients, highly cross-linked polyethylene (HXLPE) shoulder implants may improve longevity and performance while reducing the need for revision surgeries.
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Improving Total Knee Implants by Discovering Fatigue Mechanisms
The development of advanced materials at the Massachusetts General Hospital Harris Orthopaedics Laboratory is leading to improvements in total knee arthroplasty (TKA) components’ wear rates.
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Outcomes of Metal-on-Metal THA Poorer with Modular Stems
Many failures of metal-on-metal total hip arthroplasty are due to adverse local tissue reactions, which are associated with elevated metal ion levels due to implant wear. Mass General surgeons wondered whether the modular S-ROM stem, which has an additional metal-on-metal interface, influences outcomes.
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Novel Drug-eluting Polymer May Improve Treatment of Prosthetic Joint Infection
The standard treatment for prosthetic joint infection requires patients to endure two surgeries beyond the original procedure, plus periods of inactivity. A new drug-eluting polymer developed at Mass General might change all that.
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Highly Cross-Linked Polyethylene Performs Well in Implants
A 17-year follow-up study of patients with hip replacements made of HXLPE shows that use of HXLPE in prosthetic hips has reduced wear by 90% versus conventional polyethylene and has almost totally eliminated periprosthetic osteolysis.
Biography
Orhun K. Muratoglu, PhD, is the Director of the Harris Orthopaedics Laboratory and Director of the Technology Implementation Research Center (TIRC) at Massachusetts General Hospital, Alan Gerry Scholar at Mass General, and Professor of Orthopedic Surgery at Harvard Medical School. He received his B.S. from Rennselaer Polytechnic Institute in Materials Science and completed his doctoral work at the Massachusetts Institute of Technology in the Program for Polymer Science and Technology. Dr. Muratoglu played a key role in the discovery of highly cross-linked UHMWPE, a more wear-resistant polymeric material for load-bearing applications in total joints. He also pioneered the use of the antioxidant vitamin E to further stabilize the highly cross-linked UHMWPE. Medical implants fabricated using technologies developed by Dr. Muratoglu have been in clinical use since 1998, with over 7 million implantations worldwide. Dr. Muratoglu continues his research on UHMWPE and infection and pain management technologies in total joints. He also directs research in the design of more functional joint implants at the TIRC.
Orthopaedic Care at Mass General
At Mass General, our world-class physicians and surgeons treat the full spectrum of musculoskeletal conditions throughout the body, from sprains and strains on the athletic field to carpal tunnel syndrome. Our team offers innovative, research-based treatments that range from limb-saving oncological procedures to complex spinal reconstruction.