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Featured
Research Contributing to Successful COVID-19 Vaccine Development
Galit Alter, PhD, is a principal investigator at the Ragon Institute. She discusses her COVID-19 research that has been important for developing the critical insights into the antibody mechanisms that are essential to induce through vaccination to control and clear the infection.
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T Cell Response to Omicron Preserved With Prior COVID-19 Infection, Vaccination
Massachusetts General Hospital investigators evaluated T cell immune responses to the SARS-CoV-2 Omicron variant and found that individuals with prior COVID-19 infection or vaccination have a robust T cell response against Omicron, despite low antibody responses.
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Protection After First Dose of COVID-19 mRNA Vaccines Slower to Develop in Pregnant Women
Andrea Edlow, MD, MSc, of the Department of Obstetrics and Gynecology, and colleagues discovered antibody profiles induced by the COVID-19 mRNA vaccines develops more slowly than normal in pregnant/lactating women. This highlights the critical need to administer two doses at the recommended interval in pregnancy.
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Medical Grand Rounds: The Omicron Surge: Testing, Clinical Aspects, Vaccines, and Global Implications
Ruanne Barnabas, MBChB, MSc, DPhil, chief of the Division of Infectious Diseases at Massachusetts General Hospital, and members of the Boston medical community discuss clinical aspects and global implications of the omicron surge.
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Severe Allergic Reactions Are Rare with COVID-19 mRNA Vaccines
A prospective study of employee mRNA COVID-19 vaccination at Mass General Brigham linked self-reported history of high-risk allergy to increased risk of self-reported allergic reactions, but only 0.3% of employees had severe reactions and the vast majority completed the two-dose series.
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The Role of Immunosuppressives in Breakthrough COVID-19 Infections Among Rheumatic Patients
Zachary S. Wallace, MD, MSc, at Massachusetts General Hospital has been tracking breakthrough COVID-19 infections among vaccinated patients with rheumatic diseases. He and Mass General Brigham colleagues have observed that those with breakthrough infections are having an inadequate immune response to the vaccines.
Vaccine Contributors
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Bruce Walker, MD
Director of the Ragon Institute of MGH, MIT and Harvard, Director of the Harvard University Center for AIDS Research
Recent Article
Medical Grand Rounds: Evolution of the COVID-19 Pandemic: Implications for Vaccines, Treatment -
Galit Alter, PhD
Principal Investigator, Ragon Institute, Massachusetts General Hospital, Samana Cay MGH Research Scholar
Recent Article
Dysregulated Antibody Response Implicated in Severe COVID-19 in Adults and Multisystem Inflammatory Syndrome in Children
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Kimberly G. Blumenthal, MD, MSc
Director of Research, Drug and Vaccine Allergy Center, Co-Director, Clinical Epidemiology Program, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Assistant Professor of Medicine, Harvard Medical School
Recent Article
Most Prior Drug Allergies Can Be Disproved in Older Adults
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Luk Vandenberghe, PhD
Associate Professor of Ophthalmology, Harvard Medical School, Grousbeck Family Chair in Gene Therapy and Director of the Grousbeck Gene Therapy Center, Mass Eye and Ear
Recent Article
Developing a Gene-based Vaccine Candidate for COVID-19
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Mark C. Poznansky, MD, PhD
Director, Vaccine and Immunotherapy Center, Infectious Disease Division, Massachusetts General Hospital, Associate Professor of Medicine, Harvard Medical School, Attending Physician, Infectious Disease Division
Recent Article
MGH Research Scholars Respond to COVID-19 -
Mason Wright Freeman, MD
Director and Founder, Mass General Translational Research Center
Recent Article
Why Pursuing Multiple Vaccines May Be the Best Way to End the COVID-19 Pandemic -
Richelle Candice Charles, MD
Principal Investigator in the Division of Infectious Diseases, Massachusetts General Hospital, Assistant Professor of Medicine, Harvard Medical School
Recent Article
Medical Grand Rounds: Evolution of the COVID-19 Pandemic: Implications for Vaccines, Treatment
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Rochelle P. Walensky, MD, MPH
Former Chief, Division of Infectious Diseases, Professor of Medicine, Harvard Medical School, Steve and Deborah Gorlin MGH Research Scholar
Recent Article
COVID-19 Vaccines: Proper Implementation as Important as Efficacy
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Zachary S. Wallace, MD, MSc
Co-Director, Rheumatology Vasculitis Program, Physician, Rheumatology Unit, Massachusetts General Hospital, Assistant Professor of Medicine, Harvard Medical School
Recent Article
Mass General Program One of the Few in the World to Focus on Vasculitis Patients
