Posts by Raul Mostoslavsky, MD, PhD
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Harnessing Cancer Metabolomics to Transform Therapeutic Discovery
Researchers at Massachusetts General Hospital won a Breakthrough Award to elucidate the central roles of cancer metabolism in tumor survival and metastasis.
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Enhanced Glycolysis Is a Main Driver in Squamous Cell Carcinoma
Raul Mostoslavsky, MD, PhD, and colleagues present the first comprehensive evidence that metabolic reprogramming to increase glycolysis is critical for nucleotide synthesis and antioxidative function in tumor-propagating cells in squamous cell carcinoma, making those cells a novel potential therapeutic target.
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Inactivating Mutation in the Histone Deacetylase SIRT6 Discovered to Be a Cause of Fetal Demise
Showing for the first time that a chromatin regulator can underlie perinatal lethality, Massachusetts General Hospital Cancer Center researchers have identified a loss-of-function mutation in SIRT6 that was associated with four cases of severe congenital anomalies and late fetal death.
Mass General Cancer Center
An integral part of one of the world’s most distinguished academic medical centers, the Massachusetts General Hospital Cancer Center is among the leading cancer care providers in the United States.
