Dr. Perlis is the associate chief for research in the Department of Psychiatry and director of the Center for Quantitative Health in the Division of Clinical Research at Massachusetts General Hospital, the Associate Director of the Psychiatric Genetics Program in Mood and Anxiety Disorders and Professor of Psychiatry at Harvard Medical School. He also serves as consultant to the American Psychiatric Association's bipolar treatment guidelines workgroup.
A graduate of Brown University, Harvard Medical School and Harvard School of Public Health, he completed his residency, chief residency, and clinical/research fellowship at Mass General before joining the faculty.
Dr. Perlis' clinical work and research is focused on difficult-to-treat or treatment resistant mood disorders, including major depressive disorder and bipolar disorder. He has authored more than 125 articles reporting original research, as well as numerous book chapters and reviews.
Current research efforts include identifying genetic variations which might predict treatment response, creating neuronal models of disease, and identifying and studying novel treatments for mood disorders. His research has been supported by awards from NARSAD, NIMH, NSF, the American Philosophical Society, the Bowman Family Foundation, and the Stanley Center for Psychiatric Research, among others. In 2010 Dr. Perlis was awarded the Depression and Bipolar Support Alliance's Klerman Young Investigator Award.