Posts by Ebru Oral, PhD
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Novel Model for Evaluation of Pain Treatments for Long-Bone Fracture
Massachusetts General Hospital orthopedic surgeons have developed a rat model in which gait and weightbearing are markers of recovery after repair of tibia fracture. Their long-term aim is to use the model to compare locally non-opioid analgesics to current pain management methods for long-bone fracture.
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Polyethylene Loaded With Dual Analgesics Has Synergistic Effects Against Staphylococci
Dmitry Gil, PhD, Ebru Oral, PhD, and colleagues showed ultra–high-molecular-weight polyethylene loaded with bupivacaine and tolfenamic acid had synergistic effects against Staphylococci, suggesting the material could provide not just post-arthroplasty pain relief but also short-term antibacterial prophylaxis.
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Advances in Arthroplasty From the Harris Orthopaedics Lab: Maximizing Safety and Effectiveness
The Harris Orthopaedic Laboratory at Massachusetts General Hospital is driving research and innovation to eliminate infection and improve pain management related to total joint arthroplasty.
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Vitamin E Protects Bone Allografts Undergoing Radiation Sterilization
Vitamin E, a biocompatible free radical scavenger, is an effective and feasible radioprotectant when bone allografts are sterilized with ionizing radiation.
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Improvements in Outcomes for Total Joint Patients from the Harris Lab
In this video, Orhun Muratoglu, PhD, director of Harris Orthopaedics Laboratory at Massachusetts General Hospital, and Ebru Oral, PhD, associate director of biomaterials at Harris Orthopaedics Laboratory, discuss their work in improving outcomes in total joint patients.
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New Polymer for Joint Implants Retains Superior Toughness When Produced at Scale
A vitamin E–blended, peroxide cross-linked, high-temperature ultrahigh molecular weight polyethylene, created at Massachusetts General Hospital, is a promising material for manufacturing joint implant bearing surfaces due to a single-step consolidation/cross-linking process and resulting superior properties.
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Research Advances from Mass General Orthopaedics
Researchers from the Department of Orthopaedics discuss the clinical and translational work they are doing at Massachusetts General Hospital.
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Reducing Infection in Total Joint Replacements with Drug-Eluting Implants
Researchers at Massachusetts General Hospital have developed a promising new drug-eluting joint implant technology adding antibiotics to ultra-high molecular weight polyethylene (UHMWPE) material.
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Improving Total Knee Implants by Discovering Fatigue Mechanisms
The development of advanced materials at the Massachusetts General Hospital Harris Orthopaedics Laboratory is leading to improvements in total knee arthroplasty (TKA) components’ wear rates.
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Novel Drug-eluting Polymer May Improve Treatment of Prosthetic Joint Infection
The standard treatment for prosthetic joint infection requires patients to endure two surgeries beyond the original procedure, plus periods of inactivity. A new drug-eluting polymer developed at Mass General might change all that.
Biography
Dr. Oral received her BS degree from Bogaziçi University in chemical engineering. She did her graduate work under the direction of Dr. Nicholas Peppas at Purdue University with specialization in polymeric biomaterials for therapeutic systems and received her PhD in chemical engineering in 2003. She did her post-doctoral training in orthopaedic biomaterials at the Harris Orthopaedics Laboratory from 2003 to 2005 on antioxidant stabilization methods of cross-linked polyethylenes for joint implants. Her post-doctoral work received the HAP Paul Award of the International Society for Technology in Arthroplasty. She was appointed an instructor in 2005 and focused on improving the mechanical strength of current polymeric materials used in joint implants and medical devices. She was named American Academy of Orthopaedics Surgeons/National Institutes of Health Young Investigator on Wear and Osteolysis in 2007 and she again received the HAP Paul Award of the ISTA in 2011. She was named a Claflin Distinguished Scholar at Mass General in 2011 and became a Lifetime Honorary Member of the International Society for Technology in Arthroplasty in 2013. She was promoted to assistant professor in orthopaedic surgery at Harvard Medical School in 2013 and focuses on addressing musculoskeletal problems using material strategies while leading the polymeric development work at Harris Orthopaedics Laboratory. She has published over 40 peer-reviewed papers and numerous book chapters. She is also an inventor of a number of material technologies for joint implants with over 90 patents and patent applications. In addition to her research, she is an educator to biomedical engineering technicians, post-doctoral fellows, medical students and colleagues, technicians and technologists.
Orthopaedic Care at Mass General
At Mass General, our world-class physicians and surgeons treat the full spectrum of musculoskeletal conditions throughout the body, from sprains and strains on the athletic field to carpal tunnel syndrome. Our team offers innovative, research-based treatments that range from limb-saving oncological procedures to complex spinal reconstruction.