Jill M. Goldstein, Ph.D. is Founder and Executive Director of the Innovation Center on Sex Differences in Medicine (ICON) at Massachusetts General Hospital (MGH), the Helen T. Moerschner Endowed MGH Research Institute Chair in Women’s Health, and Professor of Psychiatry and Medicine, Harvard Medical School. She is a clinical neuroscientist and expert in understanding sex differences in health and diseases associated with the central nervous system, and their co-occurrence with general medicine, e.g., cardiovascular disease (CVD). Her science has focused on prenatal and early life exposures and risk for sex differences in the co-occurrence of these disorders across the life course, in particular, major depression, CVD and Alzheimer’s disease. Her program of research (funded by National Institute of Health (NIH) for >30 years) called the Clinical Neuroscience Laboratory of Sex Differences in the Brain, consists of an interdisciplinary team of investigators integrating brain imaging, physiology, neuroendocrinology, genetics, immune function, and collaborations with animal studies of sex differences in hormones and the brain. Dr. Goldstein has received numerous awards for her work on sex differences in the brain, served on scientific review boards, and participated in strategic planning for NIMH, NIH Office of Research on Women’s Health, and the Institute of Medicine. She has spent her career at Harvard training the next generation of women and men in women’s health and sex differences in medicine, including leading an ORWH Harvard K12 training program on building interdisciplinary careers in women’s health. The mission of ICON (http://icon.mgh.harvard.edu), is to tackle the co-occurrence of major depression, CVD, and AD by applying a sex differences lens across the lifespan that will integrate shared causes and consequences to more effectively develop personalized sex-dependent therapeutics.