Posts by Jorge Sepulcre, MD, PhD
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MRI Shows Small Vessel Degeneration Is Bidirectional Between Gray and White Matter
Researchers at Massachusetts General Hospital confirmed that in human cerebral small vessel disease, primary damage to white matter can cause remote damage in gray matter—but the reverse also occurs. This suggests a new framework for investigating the mechanisms and potential therapies for this disease.
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Functional MRI Shows How Parkinson's Disease Disrupts Neuronal Circuits
Radiology researchers Silvia Basaia and Jorge Sepulcre, MD, PhD, DMSc, and colleagues characterized large-scale brain propagation pathways associated with α-synuclein neural protein spreading and identified different patterns of functional connectivity disruptions in patients at different stages of Parkinson's disease.
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Review: Understanding Neuroimaging–Genetic Intersections in the Human Brain
Ibai Diez, PhD, and Jorge Sepulcre, PhD, DMSc, MD, of the Gordon Center for Medical Imaging, explain how neuroimaging findings are being combined with genetic data—research that might lead to disease-modifying therapies for neurodegenerative diseases.
Biography
Jorge Sepulcre is an Associate Professor at the Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Harvard Medical School. His research focuses on brain imaging studies aiming at the understanding of large-scale brain networks implicated in human cognition and neurodegenerative disorders such as Alzheimer's disease. He uses functional connectivity MRI and network theory techniques to untangle network properties of the human brain.
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