Posts by Chin-Lee Wu, MD, PhD
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Multiparametric MRI Is Often False-Negative for Clinically Significant Prostate Cancer
Chin-Lee Wu, MD, PhD, Douglas M. Dahl, MD, and colleagues found that 15% of patients who had negative prostate multiparametric MRI (mpMRI) were diagnosed by 20-core standard template biopsy as having clinically significant prostate cancer. They recommend considering standard biopsy regardless of negative mpMRI.
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Combined Standard and Targeted Transperineal Biopsies Advised for Patients With Prostate Lesion on Multiparametric MRI
Massachusetts General Hospital researchers recommend patients who have a prostate lesion on multiparametric MRI should undergo both standard and targeted biopsy using the transperineal approach, as that resulted in a Gleason grade most concordant with the results from radical prostatectomy specimens.
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Case Series: Mucinous Adenocarcinoma of the Prostatic Urethra After Brachytherapy for Prostatic Adenocarcinoma
Massachusetts General Hospital researchers present the first case series of brachytherapy-associated mucinous adenocarcinoma of the prostatic urethra, reviewing clinical and pathologic differences from its radiation-independent counterpart and concluding it's associated with lower stage and less aggressive behavior.
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Pathology Exam Protocol Proposed for Gender-affirming Orchiectomy Specimens
In most specimens from patients who underwent gender-affirming orchiectomy, Massachusetts General Hospital researchers identified absent or markedly reduced quantity of Leydig cells, epithelial hyperplasia, nuclear cytomegaly, and reduced tubular diameter. They propose a grossing protocol for adequate evaluation.
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Targeted Biopsy Alone Detects Clinically Significant Cancer in Smaller Prostates
Douglas M. Dahl, MD, Chin-Lee Wu, MD, PhD, and colleagues found that in patients with smaller prostates (≤30 mL), transperineal multiparametric MRI-targeted biopsy alone does as well as the combination of targeted and conventional biopsy at detecting clinically significant cancer.
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MRI–Ultrasound Fusion–Targeted Transperineal Prostate Biopsy Complements Standard Biopsy for Detecting Perineural Invasion
Chin-Lee Wu, MD, PhD and Douglas M. Dahl, MD, of the Department of Urology, and colleagues detected perineural invasion in 32% of men with suspicious prostate lesions by combining transperineal MRI–ultrasound fusion–targeted prostate biopsy with standard 20-core template transrectal biopsy.
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Prostate Cancer Patients with Posterior Positive Surgical Margins Have Poorer Prognosis
Shulin Wu, MD, PhD, and Chin-Lee Wu, MD, PhD, of the Departments of Urology and Pathology, present evidence that prostate cancer patients who have posterior positive surgical margins (PSM) after radical prostatectomy have a more aggressive disease than those with anterior PSM.
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Computational Fluid Dynamics to Assess Urine Flow After Surgery for Benign Prostatic Hyperplasia
Chin-Lee Wu, MD, PhD, and colleagues have developed an innovative computational fluid dynamics model that simulate urine flow behavior within the prostatic urethra after transurethral surgery for benign prostatic hyperplasia.
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New Research Indicates Promising Future for Prostate Cancer Diagnosis
Research conducted by Dr. Adam Feldman, Dr. Leo Cheng, and colleagues shows promising results for a non-invasive technique detecting metabolic signature between benign and cancerous prostate tissue.
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Review: Updates in Histologic Grading of Urologic Neoplasms
Pathologists at Massachusetts General Hospital recently reviewed histologic grading of renal cell carcinoma, prostate cancer and urothelial neoplasms.
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Review: Updates in Staging and Reporting of Genitourinary Malignancies
Pathologists at Massachusetts General Hospital urge colleagues to become aware of changes in the tumor, node, metastasis classification of prostate, penile, testicular, bladder, urethral, renal pelvis/ureter and kidney cancers.
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Risk of Prostate Cancer Recurrence Correlates With Number of Perineural Invasion Foci
The number of perineural invasion foci in radical prostatectomy specimens is a useful new method of prognostication.
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Review: Renal Cell Carcinomas Associated with Microphthalmia Transcription Factors
What clinicians should know about the rare subtypes of renal cell carcinoma that are characterized by rearrangement of the microphthalmia transcription factors TFE3 and TFEB.
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Laterality of Renal Cell Carcinoma Predicts Survival in Certain Patient Subgroups
Patients with right-sided renal cell carcinoma are significantly more likely to have favorable clinicopathological features than patients with left-sided disease, and they have significantly better cancer-specific survival within certain subgroups.
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Low-risk Incidental Prostate Cancer in Men with Bladder Cancer May Be Associated with Longer Survival
Men with bladder cancer who have low-risk prostate cancer detected incidentally by radical cystoprostatectomy may actually have a more favorable prognosis than those who do not.
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New Target Discovered for Prostate Cancer Immunotherapy
Genitourinary pathologists at Massachusetts General Hospital are the first to demonstrate that PD-L1 expression is highly prevalent in prostate tumor-associated nerves. Such nerves may represent an important target for immunotherapy regimens.
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Crucial miRNA–mRNA Regulatory Network Involved in Prostate Carcinogenesis Identified
Massachusetts General Hospital investigators identified miRNAs-mRNA pairs involved in prostate cancer and constructed a prostate cancer gene network based on these pairs and their connected biological pathways.
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Stress-Inducible Gene May Promote Aggressive Bladder Cancer
A team including Massachusetts General Hospital researchers have found that a stress-inducible gene known as IER3 seems to promote aggressive progression of bladder cancer.
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Novel Assessment Method Aims to Reduce Overtreatment of Prostate Cancer
Researchers at Massachusetts General Hospital have demonstrated, for the first time, that metabolic profiles of prostatectomy samples can differentiate tumor grade and stage, differentiate cancer aggressiveness and help predict recurrence and survival.
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Multifocality and Multilocation of Positive Margins Predict Biochemical Recurrence of Prostate Cancer
For patients with localized prostate cancer, multifocality and multilocation of positive surgical margins is associated with increased risk of biochemical recurrence, according to a retrospective study by Massachusetts General Hospital.
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SRPK2 May Have Key Role in Prostate Cancer Progression and Metastasis
Urologists have demonstrated for the first time that SRPK2, a cell-cycle regulator protein, is upregulated in human prostate cancer and contributes to disease progression and metastasis.
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Aromatase Expression in Bladder Tumors is Associated with Cancer Progression
Scientists at Mass General have demonstrated that aromatase in bladder tumors is involved in disease progression and may be a prognostic factor.
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Modified Paclitaxel Plus Daily Radiation Helps Noncystectomy Candidates
Physicians at Massachusetts General Hospital are in the early stages of testing a novel regimen for patients with muscle-invasive urothelial bladder cancer who are medically unfit for radical cystectomy or platinum-based radiosensitizing chemotherapy.
Biography
Dr. Wu is recognized internationally as a Genitourinary Pathology specialist. In recent years he developed a genitourinary tumor bank for teaching and research purposes. He consults as needed for particularly difficult urologic pathology specimens encountered by other staff pathologists who do not specialize in prostate, bladder and kidney cancer. Dr. Wu is a member of the Dana Farber-Harvard Cancer Center research team, and has his research laboratory in the Pathology Department at Massachusetts General Hospital.
Urology Care at Mass General
The Department of Urology at Massachusetts General Hospital offers sophisticated, compassionate care and the most innovative treatments for patients with any type of urological condition.