The American College of Cardiology's Annual Scientific Session & Expo

The American College of Cardiology will host its 2025 Annual Scientific Session & Expo in Chicago, IL, on March 29 – 31, 2025. ACC 2025 is your time to network with colleagues, see the latest science and innovation, and learn about practice-changing updates in care.

ACC 2025 includes 300+ sessions and late-breaking clinical research across 11 learning pathways on cardiovascular care at a global scale. View the Schedule-At-A-Glance for additional details.

March 29, 2025

Innovations and Insights in Heart Failure With Preserved Ejection Fraction: Emerging Therapies, Biomarkers and Mechanistic Studies

Moderator of Session 904: 9:30 a.m. – 11:30 a.m.
Akshay Desai, MD, MPH
Brigham and Women's Hospital

Changes in Apolipoprotein B and Low-Density Lipoprotein Cholesterol and Cardiovascular Events With Pemafibrate Therapy

Presentation in Session 1021: 9:30 a.m. – 10:30 a.m.
Brendan Everett, MD, MPH
Brigham and Women's Hospital

Feasibility of Combination SGLT2i and GLP-1RA for Type 2 Diabetes and ASCVD: Report From the Pilot Phase of the PRECIDENTD Pragmatic RCT

Presentation in Session 1021: 9:30 a.m. – 10:30 a.m.
Brendan Everett, MD, MPH
Brigham and Women's Hospital

Contemporary Recurrent Pericarditis Management- Real-World Evidence of Limited Cardiac Magnetic Resonance Imaging Prior to Initiating Rilonacept

Presentation in Session 1029: 9:30 a.m. – 10:30 a.m.
Brittany Weber, MD, PhD
Brigham and Women's Hospital

Coronary Computed Tomography Angiography-Derived High-Risk Shear Stress and Plaque Metrics Identify Coronary Plaques Associated With Future Acute Coronary Syndromes

Presentation in Session 1024: 9:30 a.m. – 10:30 a.m.
Mona Engy Suzan Ahmed, MD, PhD
Brigham and Women's Hospital

Treatment in Transthyretin Amyloid Cardiomyopathy: Biomarkers, Artificial Intelligence and Clinical Insights

Moderator of Session 905: 9:30 a.m. – 11:30 a.m.
Michael Givertz, MD
Brigham and Women's Hospital

Differences in Clinical Prescribing Patterns of Oral Anticoagulants Among U.S. Subpopulations

Presentation in Session 900: 9:30 a.m. – 11:30 a.m.
Rahul Aggarwal, MD
Brigham and Women's Hospital

Variation in Cardiopulmonary Risk Among 3.4 Million Medicare Beneficiaries With Chronic Obstructive Pulmonary Disease By Race/Ethnicity and Income

Presentation in Session 1041: 11:00 a.m. – 12:00 p.m.
Muthiah Vaduganathan, MD, MPH
Brigham and Women's Hospital

Long-Term Implications of Hypertension in Pregnancy: Postpartum Cardiovascular Risk Assessment and Reduction Across the Lifecourse

Presentation in Session 204: 11:30 a.m. – 12:30 p.m.
Michael Honigberg, MD, MPP
Massachusetts General Hospital

Finerinone: A Promising Addition to the Aramamentarium or Merely an Academic Exercise?

Moderator of Session 920: 12:00 p.m. – 2:00 p.m.
Akshay Desai, MD, MPH
Brigham and Women's Hospital

Transthyretin Amyloidosis: Outcomes, Health Status and Transplantation

Moderator of Session 919: 12:00 p.m. – 2:00 p.m.
Michael Givertz, MD
Brigham and Women's Hospital

Let's Be Real: Initiation and Optimization of Heart Failure Core Medications in Ambulatory and Inpatient Care

Co-Chair of Session 217: 1:30 p.m. – 2:30 p.m.
Muthiah Vaduganathan, MD, MPH
Brigham and Women's Hospital

Case Carousel: Rapid-Fire Cardiovascular Imaging Cases

Co-Chair of Session 221: 1:30 p.m. – 2:30 p.m.
Meagan Wasfy, MD
Massachusetts General Hospital

Cardiopulmonary Exercise Testing: Setting the Stage I

Panelist in Session 853: 2:00 p.m. – 3:00 p.m.
Meagan Wasfy, MD
Massachusetts General Hospital

Hands-on Learning: HCM Diagnosis and Treatment With CPET Basics II

Panelist in Session 810: 2:00 p.m. – 4:30 p.m.
Meagan Wasfy, MD
Massachusetts General Hospital

Cardiovascular-Kidney-Metabolic Syndrome Risk Factor Prevalence, Treatment, and Control Among South Asian and Chinese Americans

Presentation in Session 931: 2:30 p.m. – 4:30 p.m.
Rahul Aggarwal, MD
Brigham and Women's Hospital

Critical Care Cardiology Perspectives: Shocking Headlines in Cardiogenic Shock

Moderator of Session 938: 2:30 p.m. – 4:30 p.m.
David Morrow, MD, MPH
Brigham and Women's Hospital

Factor XI Inhibition With Abelacimab in Atrial Fibrillation Across the Spectrum of Bleeding Risk

Presentation in Session 930: 2:30 p.m. – 4:30 p.m.
Siddharth Patel, MD, MPH
Brigham and Women's Hospital

Bleeding With the FXI Inhibitor Abelacimab Compared With Rivaroxaban in Older Individuals With Atrial Fibrillation: Analysis of the AZALEA-TIMI 71 Trial

Presentation in Session 939: 2:30 p.m. – 4:30 p.m.
Samer Al Said, MD, DrMed
Brigham and Women's Hospital

Hemostasis vs. Thrombosis: What is the Role of Factor XI?

Presentation in Session 3001: 5:30 p.m. – 7:30 p.m.
Jean Connors, MD
Brigham and Women's Hospital

March 30, 2025

Zipes Distinguished Young Scientist Awardee Keynote: Cardio-Rheumatology - Cardiovascular Prevention in the Face of Systemic Inflammatory Disease

Presentation in Session 304: 8:00 a.m. – 9:00 a.m.
Brittany Weber, MD, PhD
Brigham and Women's Hospital

Debate: Ablation Is Best for Atrial Fibrillation in the Endurance Athlete!

Presentation in Session 307: 8:00 a.m. – 9:00 a.m.
Eugene Chung, MD, MPH
Massachusetts General Hospital

How Much LV Dysfunction Is Okay? What About a Little Heart Failure?

Presentation in Session 311: 8:00 a.m. – 9:00 a.m.
Anju Nohria, MD, MSc
Brigham and Women's Hospital

Mode of Death in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The FINEARTS-HF Trial

Presentation in Session 949: 9:00 a.m. – 11:00 a.m.
Akshay Desai, MD, MPH
Brigham and Women's Hospital

Cardiovascular CT in Future Guidelines - What Data Do We Need?

Session 305: 8:00 a.m. – 9:00 a.m.
Ron Blankstein, MD 
Brigham and Women's Hospital

Comparative Effectiveness of Balloon Aortic Valvuloplasty With Non-Compliant and Compliant Balloons in the Era of Transcatheter Aortic Valve Replacement (TAVR) and Radial Access

Presentation in Session 948: 9:00 a.m. – 11:00 a.m.
Jonathan Fang, MD 
Brigham and Women's Hospital

Longitudinal Outcomes of the Athlete Early Repolarization Pattern in Professional Athletes

Presentation in Session 953: 9:00 a.m. – 11:00 a.m.
Eugene Chung, MD, MPH
Massachusetts General Hospital

Joint American College of Cardiology/New England Journal of Medicine Late-Breaking Clinical Trials V

Chair of Session 107: 10:00 a.m. – 11:00 a.m.
Jane Leopold, MD 
Brigham and Women's Hospital

Joint American College of Cardiology/New England Journal of Medicine Late-Breaking Clinical Trials V

Panelist of Session 107: 10:00 a.m. – 11:00 a.m.
Douglas Drachman, MD 
Massachusetts General Hospital

Cardio-Ob Team 1: Lead

Participant in Session 326: 10:00 a.m. – 11:00 a.m.
Colleen Harrington, MD
Massachusetts General Hospital

How I Approach Atrial Fibrillation in Athletes: Prioritize Ablation

Presentation in Session 320: 10:00 a.m. – 11:00 a.m.
Eugene Chung, MD, MPH
Massachusetts General Hospital

How I Approach Ischemia in My Master’s Athlete: Prioritize Medical Therapy

Presentation in Session 320: 10:00 a.m. – 11:00 a.m.
Meagan Wasfy, MD
Massachusetts General Hospital

Discovery and Validation of Plasma Renin and TNF-Related Apoptosis-Inducing Ligand (TRAIL) As Circulating Biomarkers of Heart Failure Risk in Patients With Type 2 Diabetes Mellitus

Presentation in Session 1152: 10:30 a.m. – 11:30 a.m.
David Berg, MD, MPH 
Brigham and Women's Hospital

Frailty and Valvular Disease in Elderly Women

Presentation in Session 339: 11:30 a.m. – 12:30 p.m.
Colleen Harrington, MD
Massachusetts General Hospital

Talking About the New ACS Guidelines

Co-Chair of Session 333: 11:30 a.m. – 12:30 p.m.
Michelle L. O'Donoghue, MD, MPH 
Brigham and Women's Hospital

Late-Breaking Clinical Trials VI

Co-Chair of Session 108: 11:30 a.m. – 12:30 p.m.
Douglas Drachman, MD 
Massachusetts General Hospital

Talking About the New ACS Guidelines

Panelist of Session 333: 11:30 a.m. – 12:30 p.m.
David Morrow, MD, MPH 
Brigham and Women's Hospital

A Clinical Imaging-Based Approach to Systemic Inflammatory Diseases

Co-Chair of Session 337: 11:30 a.m. – 12:30 p.m.
Brittany Weber, MD, PhD
Brigham and Women's Hospital

From Coronary Artery Calcium to Fat Attenuation Index: The Role of CT Imaging in Cardio-Rheum

Presentation in Session 337: 11:30 a.m. – 12:30 p.m.
Brittany Weber, MD, PhD
Brigham and Women's Hospital

What's New in the World of Hypertrophic Cardiomyopathy

Moderator of Session 964: 11:30 a.m. – 12:30 p.m.
Neal Lakdawala, MD
Brigham and Women's Hospital

Association of Health-related Social Needs With Adverse Pregnancy Outcomes Among Black and Latina Individuals

Presentation in Session 1165: 12:00 p.m. – 1:00 p.m.
Michael Honigberg, MD, MPP
Massachusetts General Hospital

Coping With Bad Outcomes, Patient Loss, and Medical Errors as a Trainee and Young Professional

Lounge and Learn Pavilion: 12:30 p.m. – 1:30 p.m.
Amanda C. Garfinkel, MD
Brigham and Women's Hospital

Meet the Guideline Author: New Acute Coronary Syndromes Guidelines

Special Topics 504: 12:45 p.m. – 1:15 p.m.
Michelle L. O'Donoghue, MD, MPH (Panelist)
Brigham and Women's Hospital

Genetics of SCAD: Are We Making a Breakthrough

Presentation in Session 355: 1:30 p.m. – 2:30 p.m.
Amy Sarma, MD 
Massachusetts General Hospital

Postpartum Management of Patients With SCAD

Presentation in Session 355: 1:30 p.m. – 2:30 p.m.
Nandita Scott, MD 
Massachusetts General Hospital

Thromboembolic Disease: From PE to CTEPH to Cure!

Panelist of Session 364: 1:30 p.m. – 2:30 p.m.
Jane Leopold, MD 
Brigham and Women's Hospital

Aortic Valvular Regurgitation: Five Diagnostic and Management Challenges

Presentation in Session 350: 1:30 p.m. – 2:30 p.m.
Patrick O'Gara, MD
Brigham and Women's Hospital

Get 'A's on Your Medications in Valvular Heart Disease: Antibiotics, Anticoagulants, Antiplatelets

Co-Chair of Session 362: 1:30 p.m. – 2:30 p.m.
David Dudzinski, MD, JD
Massachusetts General Hospital

When Less May Be Better: CIED Management in Chronic Illness and End of Life

Panelist in Session 363: 1:30 p.m. – 2:30 p.m.
David Dudzinski, MD, JD
Massachusetts General Hospital

Critical Care Cardiology Conundrum: A Team-Based Escape Room Challenge IV

Moderators in Session 823: 2:00 p.m. – 4:30 p.m.
Ada Stefanescu Schmidt, MDCM, MSc, FACC, and Jonathan Ludmir, MD
Massachusetts General Hospital

Lipid Control Among Parous Women With Severe Hyperlipidemia

Presentation in Session 1207: 3:00 p.m. – 4:00 p.m.
Colleen Harrington, MD
Massachusetts General Hospital

The Role of PET vs. SPECT in Predicting Cardiovascular Risks in Patients With Systemic Immune-Mediated Inflammatory Conditions

Presentation in Session 1210: 3:00 p.m. – 4:00 p.m.
Muzzamal Habib, MD
Brigham and Women's Hospital

Pulmonary Hypertension Office Hours: Ask the Experts!

Co-Chair of Session 365: 3:30 p.m. – 4:30 p.m.
Bradley Maron, MD
Brigham and Women's Hospital

Moderator: 2025 Douglas P. Zipes Distinguished Young Scientist Awardee

Moderator in Session 367: 3:30 p.m. – 4:30 p.m.
Brittany Weber, MD, PhD
Brigham and Women's Hospital

Treating Cardiovascular Disease and Diabetes: Clinical Trials to Patient Care

Co-Chair of Session 368: 3:30 p.m. – 4:30 p.m.
Jorge Plutzky, MD
Brigham and Women's Hospital

Go With the Flow: Mastering PET-Derived Coronary Flow Reserve

Panelist of Session 370: 3:30 p.m. – 4:30 p.m.
Marcelo Di Carli, MD
Brigham and Women's Hospital

Gradient Insights: Mastering 3-Vessel Disease Diagnosis With CFR and PET-FFR

Presentation in Session 370: 3:30 p.m. – 4:30 p.m.
Marcelo Di Carli, MD
Brigham and Women's Hospital

Carotid Web

Presentation in Session 380: 3:30 p.m. – 4:30 p.m.
Gaurav Parmar, MD
Massachusetts General Hospital

Featured Clinical Research III

Panelist in Session 111: 5:00 p.m. – 6:00 p.m.
Meagan Wasfy, MD
Massachusetts General Hospital

Steps to Success in the Cath Lab

Moderators in Session 383: 5:00 p.m. – 6:00 p.m.
Ada Stefanescu Schmidt, MDCM, MSc, FACC, and Douglas Drachman, MD
Massachusetts General Hospital

Cardiometabolic Mysteries: Decoding Heart Failure With Inflammation, GLP1 and SGLTi

Co-Chair of Session 391: 5:00 p.m. – 6:00 p.m.
Muthiah Vaduganathan, MD, MPH
Brigham and Women's Hospital

Multimodality Imaging in Cardiac Amyloidosis: A Clinician's Roadmap

Co-Chair of Session 385: 5:00 p.m. – 6:00 p.m.
Sharmila Dorbala, MD, MPH
Brigham and Women's Hospital

Phew, My Stress Test Was Low Risk, So No Problems, Right?

Presentation in Session 389: 5:00 p.m. – 6:00 p.m.
Sanjay Divakaran, MD, MPH, and Gary Peng, MD, PhD
Brigham and Women's Hospital

Does Only Size Matter? Use of Other Markers in Decision, When to Intervene, and Aorta Guidelines

Presentation in Session 396: 5:00 p.m. – 6:00 p.m.
Eric Isselbacher, MD
Massachusetts General Hospital

CV Health and the Environment Nexus: What Can Societies and Individuals Do to Limit Environmental Effects on Heart Disease?

Presentation at 5:27 p.m. – 5:35 p.m.
Thomas Gaziano, MD, MSc
Brigham and Women's Hospital

March 31, 2025

Novel Risk Factors in CAD

Moderator of Session 996: 9:00 a.m. – 11:00 a.m.
Nicholas Marston, MD, MPH
Brigham and Women's Hospital

Galectin-3 and Cardiovascular and Kidney Outcomes: Individual Patient Data Meta-Analysis of 74,358 Patients From 5 Multinational Clinical Trials

Presentation in Session 996: 9:00 a.m. – 11:00 a.m.
Paul Haller, MD, PhD
Brigham and Women's Hospital

Highlighted Original Research: Cardiac Disease Prevention and the Year in Review

Co-Chairs of Session 404: 9:00 a.m. – 10:00 a.m.
Michael Honigberg, MD, MPP, and Michael Osborne, MD
Massachusetts General Hospital

Molecular Imaging for ATTR Cardiac Amyloidosis: Paving the Way for Earlier Diagnosis

Presentation in Session 406: 9:00 a.m. – 10:00 a.m.
Sharmila Dorbala, MD, MPH
Brigham and Women's Hospital

Clinical Practice: New PET Perfusion Tracers on the Horizon

Presentation in Session 406: 9:00 a.m. – 10:00 a.m.
Marcelo Di Carli, MD
Brigham and Women's Hospital

PHorecasting the Pulmonary Hypertension Future

Panelist in Session 416: 9:00 a.m. – 10:00 a.m.
Bradley Maron, MD
Brigham and Women's Hospital

Precision Medicine and Multi-Omics Technologies in Pulmonary Hypertension

Presentation in Session 416: 9:00 a.m. – 10:00 a.m.
Bradley Maron, MD
Brigham and Women's Hospital

Leveraging Preexisting Cardiovascular Data to Improve the Detection and Treatment of Hypertension: The NOTIFY-LVH Randomized Clinical Trial

Presentation in Session 404: 9:00 a.m. – 10:00 a.m.
Adam Berman, MD, and Jason Wasfy, MD
Brigham and Women's Hospital; Massachusetts General Hospital

Health Equity in the Management of Arrhythmias

Moderator of Session 990: 9:00 a.m. – 11:00 a.m.
E. Kevin Heist, MD, PhD
Massachusetts General Hospital

Navigating Menopause: Strategies and Self-Care for Women in Cardiology

Presentation in Session 5060: 10:00 a.m. – 11:00 a.m.
Colleen Harrington, MD
Massachusetts General Hospital

Evolocumab and Rate of Complex Coronary Revascularizuation During 8-Year Follow-Up - Analysis of 6,635 Patients From the FOURIER OLE Trial

Presentation in Session 423: 11:00 a.m. – 12:00 p.m.
Paul Haller, MD, PhD
Brigham and Women's Hospital

Cardiovascular Imaging Editors-in-Chief as Mentors-in-Chief

Panelist of Session 419: 11:00 a.m. – 12:00 p.m.
Marcelo Di Carli, MD
Brigham and Women's Hospital

Polygenic Risk for Cardiovascular Disease Varies By Socioeconomic Status

Presentation in Session 423: 11:00 a.m. – 12:00 p.m.
Ahmed Tawakol, MD, and Michael Osborne, MD
Massachusetts General Hospital

Take It to the Limit: Cardiovascular Imaging in the Masters Athlete

Co-Chair of Session 421: 11:00 a.m. – 12:00 p.m.
Meagan Wasfy, MD
Massachusetts General Hospital

Highlighted Original Research: Ischemic Heart Diseases and the Year in Review

Year in Review Speaker of Session 423: 11:00 a.m. – 12:00 p.m.
Jason Wasfy, MD
Massachusetts General Hospital

Debate 1 (Pro): Implementation Science & GDMT Titration Strategies

Presentation in Session 426: 11:00 a.m. – 12:00 p.m.
Muthiah Vaduganathan, MD, MPH
Brigham and Women's Hospital

Computed Tomography Angiography derived High-Risk Anatomica and Shear Stress Metrics Predict Acute Coronary Syndrome: Sub analysis from the ICONIC Trial

Presentation in Session 1012: 11:30 a.m. – 1:30 p.m.
Diaa A. Hakim, MBBS, and Peter Stone, MD
Brigham and Women's Hospital

Adverse Pregnancy Outcomes and Premature Menopause Enhance Cardiovascular Risk Among Women With Severe/Familial Hypercholesterolemia

Presentation in Session 1006: 11:30 a.m. – 1:30 p.m.
Michael Honigberg, MD, MPP
Massachusetts General Hospital

Depression and Anxiety Contribute to an Increased Risk of End-stage Renal Disease Through the Development of Cardiovascular Risk Factors

Presentation in Session 1259: 11:00 a.m. – 12:00 p.m.
Michael Osborne, MD
Massachusetts General Hospital

Changes in Pulmonary Artery Pressure Following Initiation of Neprilysin or SGLT2 Inhibitors in Patients With Heart Failure: Insights From GUIDE-HF

Presentation in Session 1267: 12:00 p.m. – 1:00 p.m.
Akshay Desai, MD, MPH
Brigham and Women's Hospital

Cardiovascular Risk Factor Burden, Treatment, and Control Among Young Adults in the United States, 2013 to 2023

Presentation in Session 1259: 12:00 p.m. – 1:00 p.m.
Rahul Aggarwal, MD
Brigham and Women's Hospital

Debate: PET-Based Quantification Is Ready for Prime-Time in Cardiac Sarcoidosis

Presentation in Session 441: 1:00 p.m. – 2:00 p.m.
Sharmila Dorbala, MD, MPH
Brigham and Women's Hospital

High Acuity Valve Disease: The Great “Around the Horn” Debate

Team A: Debate 2 in Session 442: 1:00 p.m. – 2:00 p.m.
David Dudzinski, MD, JD
Massachusetts General Hospital

Bringing Logic to the Madness of Evaluating Chest Pain in ED and Outpatient Clinic

Co-Chair of Session 454: 2:30 p.m. – 3:30 p.m.
Benjamin Scirica, MD
Brigham and Women's Hospital

Cardio Clash: Faculty Face-Off on Cardiovascular Health

Co-Chair of Session 458: 2:30 p.m. – 3:30 p.m.
Kaavya Paruchuri, MD
Massachusetts General Hospital