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Medical Grand Rounds: A 50-Year Story of Lyme Arthritis

In This Article

  • Allen C. Steere, MD, has studied Lyme arthritis for over 50 years, and his journey can be traced back to the 1970s when he initially identified and described the clinical syndrome
  • Throughout decades of research, Dr. Steere's work has contributed several pivotal discoveries that improved understanding of Lyme arthritis and identified effective treatments
  • In a Grand Rounds presentation, Dr. Steere shared the story of his Lyme arthritis work and described current and future challenges with the condition

Allen C. Steere, MD, a rheumatologist and physician-scientist at Massachusetts General Hospital, is internationally recognized for his studies of Lyme disease.

His work began 50 years ago, as a post-doctoral fellow at Yale University, where he evaluated a group of children with arthritis from Lyme, Connecticut. This evaluation led to the identification and clinical description of Lyme arthritis, and Dr. Steere went on to further study the condition for decades.

In a recent Medical Grand Rounds presentation from the Department of Medicine, Dr. Steere shared the story of his 50-year journey studying Lyme arthritis. Throughout these years of work, Dr. Steere contributed several pivotal discoveries that have improved the understanding of Lyme arthritis and helped identify effective treatments and vaccines.

As director of translational research in rheumatology at Mass General and a principal investigator of the Steere Laboratory in the Center for Immunology and Inflammatory Diseases, Dr. Steere continues to study the condition to understand disease mechanisms further, identify biomarkers of disease, and develop diagnostic tests.

Andrew Luster, MD, PhD, chief of the Mass General Division of Rheumatology, Allergy and Immunology, introduced Dr. Steere's presentation, and the Grand Rounds course was directed by Jose Florez, MD, PhD, physician-in-chief and chair of the Department of Medicine.

Watch the Grand Rounds livestream here.

Learn more about the Steere Laboratory

Explore research in the Center for Immunology & Inflammatory Diseases

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In a recent Medical Grand Rounds presentation, the Division of Rheumatology, Allergy, and Immunology at Massachusetts General Hospital presented on IgG4-related disease, reviewing the disease's early history at Mass General, its major clinical manifestations, ongoing clinical trials, and more.

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Allen C. Steere, MD, and colleagues propose that CD8+ T cell–mediated cytotoxicity, CD4+ T cell help, autoantibodies to vascular antigens, and complement deposition may each have a role in microvasculature damage in post-antibiotic Lyme arthritis.