Posts by Kristopher T. Kahle, MD, PhD
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Using Cortical Tissue Immuno-analysis to Predict Outcomes in Hydrocephalus Patients
Massachusetts General Hospital researchers present evidence that when patients with idiopathic normal pressure hydrocephalus are being considered for surgical shunt placement, analysis of cortical tissue for potential Alzheimer's disease pathology may help select candidates who will have positive clinical outcomes.
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Perspective: Using Information on Somatic Mutations to Direct Management of Neurological Disorders
Kristopher T. Kahle, MD, PhD, and colleagues explain that somatic variations detected from neurosurgical biopsies or resection of fresh brain tissue are beginning to suggest which existing targeted medications could be used as monotherapies or adjuncts to surgery for non-oncologic neurological diseases.
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Review: Rethinking the Cilia Hypothesis of Hydrocephalus
Researchers at Massachusetts General Hospital urge reconsidering the idea that ciliary dysfunction leading to cerebrospinal fluid overaccumulation is an important pathophysiologic mechanism in hydrocephalus. They present human and animal evidence to the contrary and explain rationales for alternatives to shunting.
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Treatment of Congenital Hydrocephalus Should Optimize Brain Development
Kristopher T. Kahle, MD, PhD, and colleagues are shifting the understanding of how congenital hydrocephalus might best be treated, demonstrating it's a genetic defect in which neural stem cells fail to develop properly, not a simple issue of cerebrospinal fluid overaccumulation.
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Mass General Renews Focus on Pediatric Epilepsy
A new team approach at Mass General is applying advances in adult epileptics, such as epilepsy surgery and responsive neurostimulation, to children.
Biography
Dr. Kahle is the Director of Pediatric Neurosurgery at the Massachusetts General Hospital and the Harvard Center for Hydrocephalus and Neurodevelopmental Disorders (HAND). He is a board-certified pediatric neurosurgeon, with experience in a broad range of pediatric neurosurgical disorders including brain and spinal cord tumors and cysts, all types of hydrocephalus, Chiari malformation, spina bifida, vascular malformations, and others. He also treats these conditions in transitional age patients and adults, providing continuity of care across the age spectrum. He is highly skilled in both open and endoscopic/minimally invasive neurosurgical techniques.
Dr. Kahle is a fellow of the American Association of Neurological Surgeons (AANS) and a member of numerous medical organizations, including the AANS, Congress of Neurological Surgeons (CNS), American Society of Pediatric Neurosurgeons (ASPN), and the International Society of Pediatric Neurosurgeons (ISPN).
Dr. Kahle graduated cum laude from the University of Chicago in 1999 with degrees in Biology and Philosophy. He received his M.D. from Yale School of Medicine in 2007, where he also received his Ph.D. working in the laboratory of human geneticist Richard Lifton. He completed his neurosurgery residency training at Mass General in 2014, as well as a post-doctoral research fellowship at Harvard University with co-mentors Stephen Elledge and David Clapham. He completed a clinical pediatric neurosurgery fellowship at Boston Children’s Hospital, where he was Shellito staff associate and Instructor of Neurosurgery at Harvard Medical School. Dr. Kahle returned to New Haven to join the Yale School of Medicine faculty, where he was Assistant Professor of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology, and Director of Neonatal and Congenital Anomaly Neurosurgery from 2016-2021.
Neuroscience Care at Mass General
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