Posts by Lael M. Yonker, MD
-
Life-threatening COVID-19–Related Disease of Children Driven by Loss of Gut Barrier
Massachusetts General Hospital and Brigham and Women's researchers have provided evidence that gastrointestinal sources of SARS-CoV-2 antigens may instigate and drive multisystem inflammatory syndrome in children, the life-threatening immune activation syndrome associated with prior SARS-CoV-2 infection or exposure.
-
Dysregulated Antibody Response Implicated in Severe COVID-19 in Adults and Multisystem Inflammatory Syndrome in Children
Lael M. Yonker, MD, of the Department of Pediatrics; Galit Alter, PhD, core member of the Ragon Institute of Mass General, MIT and Harvard; and colleagues have uncovered an unexpected pathological role for IgA and monocyte-activating IgG antibodies in severe COVID-19 and severe MIS-C, respectively.
