Posts by Nicole Zurcher Wimmer, PhD
-
Review: The Role of Histone Deacetylases in Autism Spectrum Disorder
Massachusetts General Hospital researchers recently reviewed research on relationships between autism spectrum disorder (ASD) and histone deacetylases (HDACs), enzymes that can suppress gene transcription. Animal research and preliminary human evidence show HDAC inhibition might alleviate ASD symptoms.
-
Histone Deacetylases Appear to Have Pathophysiologic Role in Bipolar Disorder
Massachusetts General Hospital researchers have reported the first in vivo human evidence of a role for histone deacetylases in the pathophysiology of bipolar disorder as well as in two of its hallmark clinical features, emotional dysregulation and attention deficits.