Posts by Julie J. Miller, MD, PhD
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Novel Combination Therapy Highly Effective Against IDH-mutant Glioma
Adding a poly(ADP-ribose) glycohydrolase inhibitor to temozolomide was highly effective in glioma cell lines and an IDH-mutant xenograft mouse model.
Biography
Julie J. Miller, MD, PhD, is a neuro-oncologist in the Translational Neuro-oncology Laboratory at the Mass General Cancer Center. Dr. Miller is interested in understanding the genetic and molecular mechanisms driving the development and progression of primary brain tumors, particularly IDH-mutant gliomas and glioblastoma. Her recent research has focused on the disruption of normal metabolism that is observed in IDH-mutant gliomas, with the goal of developing new drugs and treatment strategies to more effectively treat patients with these tumors. She has also been exploring the molecular changes that occur in IDH-mutant gliomas following chemotherapy exposure to better understand mechanisms of resistance and develop ways to prolong the clinical benefit of chemotherapy.
Neuroscience Care at Mass General
Through a combination of unmatched expertise, creativity and compassion, Mass General Neuroscience relentlessly advances the fields of Neurosurgery, Neurology and Psychiatry to unleash our patients’ potential.