Posts by Shibani S. Mukerji, MD, PhD
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CNS Cells Can Be Reservoirs for Long-term HIV-1 Persistence Despite Antiretroviral Therapy
In autopsy samples from people treated with antiretroviral therapy, Massachusetts General Hospital researchers found intact HIV-1 proviruses in the central nervous system and other organs, and they showed brain tissue can be involved in multi-compartment dissemination of large clones of HIV-1 proviruses.
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Natural Language Processing Improves the Speed, Reliability of Determining Cognitive Status From Electronic Health Records
Massachusetts General Hospital researchers have devised a novel semiautomated approach to phenotyping cognitive status from the clinical notes in electronic health records and structured data. The new method improves interrater reliability and is significantly faster than manual review alone.
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Neuroinfectious Disease Research
Shibani S. Mukerji, MD, PhD, associate director of the Neuro-Infectious Diseases Unit of the Department of Neurology, talks about her work on neuroinfectious diseases and how they invade the nervous system.
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Using AI to Predict COVID-19 Outcomes
Shibani S. Mukerji, MD, PhD, associate director of the Neuro-Infectious Diseases Unit of the Department of Neurology, talks about her work on developing the COVID-19 Acuity Score (CoVA), which can be incorporated into an electronic health record system.
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Neuropathological Features of COVID-19
Shibani S. Mukerji, MD, PhD, of the Neuro-Infectious Diseases Unit at Massachusetts General Hospital, discusses the neuropathological features of COVID-19. In this video, She details the impact the virus has on the brain, showing that there is minimal viral presence.
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Leukoencephalopathy Related to Severe COVID-19 Has Clinical, Laboratory Correlates
Otto Rapalino, MD, and Michael H. Lev, MD, of the Department of Radiology; Shibani S. Mukerji, MD, PhD, of the Department of Neurology; and colleagues have linked severe COVID-19 leukoencephalopathy with reduced diffusivity to obesity, renal failure, hypernatremia, anemia and a pattern of white matter lesions.
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COVID-19 Acuity Score Identifies Outpatients at High or Low Risk of Adverse Outcomes
Massachusetts General Hospital researchers have developed and validated the first scoring system that triages patients with suspected or confirmed COVID-19 who do not require immediate hospitalization.
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The Neurological Effects of Sedation in COVID-19 Patients
Neurologic symptoms such as headache, confusion, altered alertness and loss of smell have been identified as symptoms of COVID-19. Although researchers are starting to understand the symptoms behind neurological sequelae from SARS-CoV-2 infection, the direct and indirect effects of SARS-CoV-2 on the brain remain unclear.
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Understanding COVID-19's Neurological Effects
Massachusetts General Hospital investigators are using unprecedented collaboration and frontline experience to better understand the neurological effects of SARS-CoV-2 infection.
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Grand Rounds: Mass General Neurologists Respond to COVID-19
Neurologists must stay alert to potential neurologic complications of COVID-19 and the drugs used to treat it.
Biography
Shibani Mukerji is the Associate Director of Neuro-Infectious Diseases Unit at MGH. Her clinical focuses are on neurology-infectious diseases, with specific interests in neurological complications and aging in people living with HIV. She received her undergraduate degree from Yale University, and her M.D. and Ph.D.(Neuroscience) from the Case Western Reserve University School of Medicine. She completed an internship in internal medicine at MGH and residency in neurology at the Partners-Harvard Neurology Residency (MGH and Brigham and Women's Hospital). Her lab focuses on HIV pathogenesis in the central nervous system.
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