Posts by J. Keith Joung, MD, PhD
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CRISPR Base Editors Can Induce Wide-Ranging Off-Target Edits in RNA
The DNA deaminases contained in CRISPR-Cas cytosine and adenine base editors can induce extensive edits in RNA—and researchers at the Massachusetts General Hospital Cancer Center have engineered improved editors that substantially reduce these unwanted effects.
Biography
J. Keith Joung, MD, PhD, is the Desmond and Ann Heathwood Research Scholar, Pathologist, and Associate Chief of Pathology for Research at Massachusetts General Hospital and is Professor of Pathology at Harvard Medical School. Dr. Joung’s lab has pioneered the development of important technologies for targeted genome editing and epigenome editing of human cells. He has received numerous awards including an NIH Director’s Pioneer Award, an NIH Director’s Transformative Research Project R01 Award, the MGH Research Scholar Award and election into the American Association of University Pathologists. Dr. Joung holds a PhD in genetics from Harvard University, an MD from Harvard Medical School and an AB in biochemical sciences from Harvard College.
Mass General Cancer Center
An integral part of one of the world’s most distinguished academic medical centers, the Massachusetts General Hospital Cancer Center is among the leading cancer care providers in the United States.
