Ramnik J. Xavier, MD, PhD, Haroon Kalam, PhD, and colleagues have identified the host transcriptome involved in various phenotypic states of Mycobacterium tuberculosis (Mtb) infection of macrophages and have pinpointed MMGT1–GPR156 signaling as a regulator of the lipid droplet formation that helps latent Mtb survive.
Ramnik J. Xavier, MD, PhD, Lingjia Kong, PhD, and colleagues have produced the largest single-cell resource for studying Crohn's disease. This atlas provides unprecedented detail about cellular and transcriptomic changes that are distinct between the small and large intestines.
Using a multi-omics approach to compare rural and urban Tanzanian populations, researchers at Massachusetts General Hospital identified 34 gut microbial factors and two metabolism pathways that modulate host immune responses.
Researchers at Massachusetts General Hospital have identified SAC1, a transmembrane lipid phosphatase, as a key regulator of xenophagy-directed bacterial clearance and show that SteA, a Salmonella-secreted effector protein, supports intracellular replication.
For patients with inflammatory bowel disease, narrative text in electronic health records was successfully used to validate associations between genetic risk scores and response to tumor necrosis factor inhibitors—a potential boon to identifying biomarkers of response to different drug classes.
Gastroenterologists at Massachusetts General Hospital are part of the Integrative Human Microbiome Project, which recently cataloged numerous molecular features of the gut microbiome that are implicated in inflammatory bowel disease.
C1orf106 is a known susceptibility gene for inflammatory bowel disease, and now Massachusetts General researchers have identified its role: it "fine tunes" the integrity of the intestinal epithelial barrier.
The Massachusetts General Hospital Digestive Healthcare Center is a collaborative practice of gastroenterologists, endoscopists, surgeons, radiologists, pathologists, hepatologists, oncologists and radiation oncologists dedicated to the prevention, diagnosis, treatment and management of digestive diseases.