Posts by Matthias Nahrendorf, MD, PhD
Acetylcholine Derived From B Cells May Protect Against Cardiovascular Disease
B cells in the bone marrow are an important source of acetylcholine, Massachusetts General Hospital researchers have discovered. B cell–derived acetylcholine regulated normal hematopoiesis and limited emergency hematopoiesis in cardiovascular disease by modulating signals produced by the bone marrow stromal niche.
Bone Marrow Vascular Pathologies Augment Supply of Leukocytes Implicated in CVD
Researchers from the Center for Systems Biology at Massachusetts General Hospital and colleagues address how three heart disease milestones—hypertension, atherosclerosis and myocardial infarction—impair the bone marrow's vascular health, suggesting a new direction for development of cardiovascular disease therapies.
MGH Research Scholars Respond to COVID-19
This video highlights how the MGH Research Scholars rapidly mobilized to address key medical and scientific challenges posed by COVID-19.
Macrophages Found to be Key Contributor to HFpEF
Macrophages expansion revealed to play a key role in HFpEF pathophysiology. Inhibiting IL-10 could be a potential therapy for the disease.
My current research interests focus on imaging of molecular processes during the healing phase after myocardial infarction. Imaging targets are innate immune cells. Monocytes and macrophages are key players with a central role in disease, including the development of heart failure. We use the entire spectrum of modalities, including MRI, nuclear and optical imaging techniques. Multimodal imaging, as well as hybrid approaches to fuse molecular data with anatomical information are aspects of particular interest. These technologies are embedded in a biologically driven research program that aims at systematic understanding of inflammation at a basic level while keeping a rigorous translational perspective. In addition, I serve as the Director of the Mouse Imaging Program at the Center for Systems Biology. In this function, I oversee the scientific and administrative aspects of a broad molecular imaging facility that comprises all modalities, lead and mentor a team of post doctoral researchers and technicians and support collaborative imaging projects with outside researchers focusing on cardiovascular disease and cancer.