Mark attended the Pennsylvania State University where he majored in Biochemistry and Molecular Biology and Nutrition. As a member of the Schreyer Honors College, his honors thesis was conducted on the synthesis and assembly of nanostructures using aqueous two-phase systems. He subsequently obtained his MD and PhD degrees at the University of Texas at Southwestern Medical Center. His dissertation work was conducted in the laboratory of Dr. Thomas Südhof where he characterized synaptic transmission in the autism-relevant synaptic cell adhesion molecules neurexin and neuroligin. After completing medical school, Mark pursued residency training in neurology at the Harvard Neurology Residency Program at Brigham and Women's and MGH, followed by a fellowship in Vascular Neurology. His research interests involve stroke recovery and neuroprotection in ischemic stroke.