Posts by Miriam Antoinette Bredella, MD
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Quantitative CT, MR Spectroscopy Confirm Negative Effects of Metabolic/Bariatric Surgery on Bone Health in Adolescents
Prospective research by Florian A. Huber, MD, Miriam Bredella, MD, MBA, and colleagues showed sleeve gastrectomy in adolescents and young adults impaired bone health, with a reduction in biomechanical bone properties and an increase in lumbar bone marrow adipose tissue compared with controls who did not undergo surgery.
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Sleeve Gastrectomy Has Similarly Detrimental Effects on Bone in Adolescents and Adults
Using quantitative CT and proton magnetic resonance spectroscopy, Miriam Bredella, MD, and colleagues observed that adolescents and adults had similar decreases in lumbar volumetric bone mineral density over the 12 months after sleeve gastrectomy, which associates with an increase in lumbar marrow adipose tissue.
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Highlights from RSNA 2020
Radiologists from Massachusetts General Hospital are well represented at the Radiological Society of North America's 106th annual meeting.
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Fat Distribution and Type Puts Women at Higher Cardiometabolic Risk
A study out of Mass General finds that gender may influence how fat is distributed and thus influence metabolic risk.
Biography
Dr. Bredella is Professor of Radiology at Harvard Medical School, Vice Chair for Faculty Affairs in the Department of Radiology, and a musculoskeletal radiologist at Mass General. In her capacity of Vice Chair for faculty Affairs, she established a Department-wide faculty mentoring program which was awarded the Program Award for Culture of Excellence in Mentoring from Harvard Medical School. She also serves as Director of the Center for Faculty Development at Mass General and has established a new office for well-being to improve the well-being of our faculty and trainees across the career span. During the COVID-19 pandemic she implemented multiple initiatives to support the emotional and physical wellbeing of our faculty with special focus on women faculty and trainees. Dr. Bredella is leading departmental initiatives to fight physician burnout and serves on the hospital Frigoletto Committee on Physician Well-Being.
Dr. Bredella co-directs the Harvard KL2/Catalyst Medical Research Investigator Training Program where she mentors clinical translational researchers across all Harvard hospitals and specialties. She has been elected to be a member of the NIH Clinical and Translational Science Awards (CTSA) Program Steering Committee and chairs several CTSA working group. She is an active member of the Diversity and Inclusion Task Forces at Mass General and Harvard Medical School where she designed successful initiatives for increasing diversity in research operations.
Dr. Bredella’s research focuses on the effects of different fat depots on bone metabolism and metabolic risk in states of under- and overnutrition. She established a multidisciplinary clinical research program in the area of metabolic imaging that combines innovative translational, clinical, and outcomes research. Since joining the faculty at Mass General, Dr. Bredella has been continuously grant-funded as PI by the NIH. She serves as a grant reviewer for the NIH, the National Science Foundation (NSF) and the Swiss National Science Foundation (SNSF).
Dr. Bredella serves on the Board of Directors and Executive Committee of the Academy of Radiology Research, the society that was instrumental in establishing the National Institute of Biomedical Imaging and Bioengineering (NIBIB). She is the recipient of multiple awards, including the Distinguished Investigator Award from the Academy of Radiology Research and the Presidents Medal of the International Skeletal Society.
Dr. Bredella established a multidisciplinary clinical research program in the area of metabolic imaging that combines innovative translational, clinical, and outcomes research. Her research focuses on the effects of different fat depots on bone metabolism in states of under- and over-nutrition. Dr. Bredella has developed new imaging techniques to quantify brown adipose tissue, intramyocellular lipids (IMCL), intrahepatic lipids, and muscle mitochondrial function and examined their effects on bone, insulin resistance and cardiovascular risk in subjects with obesity, insulin resistance, growth hormone disorders, and anorexia nervosa (AN). Since joining the faculty at Mass General, she has been continuously grant funded as principle investigator by the NIH. She serves as a grant reviewer for the NIH, the National Science Foundation (NSF) and the Swiss National Science Foundation (SNSF). Dr. Bredella is on the Editorial Boards of the Journal of Bone and Mineral Research (JBMR) and Skeletal Radiology and is a Founding Editorial Board member of the Journal of Hip Preservation Surgery. She is a member of the International Skeletal Society where she serves as Chair of the Special Scientific Session. Dr. Bredella has authored 150 peer-reviewed publications, three text books and has given over 100 national/international presentations. She is the recipient of multiple awards, including the Annual Investigator Award from the Academy of Radiology Research and the Presidents Medal of the International Skeletal Society.
Mass General Imaging
For over 100 years, the Department of Radiology at Massachusetts General Hospital has pioneered imaging technology to improve human health. Today, our researchers develop powerful new ways to diagnose and treat many diseases. From the lab to the clinic, our community of radiologists and researchers brings advances directly to our patients.