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Featured
Review: Pathways of Colorectal Carcinogenesis
Dozens of different somatic mutations have been identified in colorectal tumors, but colorectal cancer appears to develop via one of only a few distinct pathways.
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Featured
Review: Lifestyle Factors, Changes in Gut Microbiota Are Linked in Development of Colorectal Cancer
Both diet, lifestyle and the gut microbiome have been implicated in colorectal tumorigenesis. Accumulating evidence suggests these two influences are related and may point the way to better prevention strategies.
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Featured
Fiber Intake Has Survival Benefit in Patients Already Diagnosed with Colorectal Cancer
In the first prospective study of the topic, gastroenterologists and epidemiologists at Massachusetts General Hospital found that higher fiber intake after a diagnosis of nonmetastatic colorectal cancer is associated with longer survival.
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Vitamin C Might Have Clinical Benefit Against KRAS- and BRAF-mutated CRC
Shuji Ogino, MD, PhD, Mingyang Song, MBBS, ScD, and colleagues leveraged data from two large, prospective U.S. studies that showed the use of vitamin C after diagnosis of colorectal cancer with KRAS or BRAF mutations was associated with a 26% reduction in the risk of disease-specific mortality.
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Adagrasib With or Without Cetuximab Shows Activity Against CRC With KRAS G12C Mutation
Samuel J. Klempner, MD, and colleagues determined adagrasib shows promising clinical activity in pretreated patients with advanced colorectal cancer with a KRAS G12C mutation. The activity appears to be even greater in combination with cetuximab where the objective response rate was 46%.
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Likelihood of Death at Home Is Improving in Colorectal Cancer, but Sociodemographic Disparities Persist
David L. Berger, MD, Swati Sonal, MBBS, and colleagues determined in a nationwide study that U.S. patients who die of colorectal cancer are increasingly more likely to die at home than in institutionalized settings, but racial, ethnic, and social inequities in access to end-of-life care seem to persist.
Mass General Cancer Center Contributors
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Daniel C. Chung, MD
Medical Co-Director, Center for Cancer Risk Assessment, Director, High-Risk GI Cancer Clinic, Mass General Cancer Center, Professor of Medicine, Harvard Medical School
Recent Article
Pilot Study: Virtual Reality Is a Feasible Alternative to Narcotics During Colonoscopy
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David L. Berger, MD
Colorectal and Gastrointestinal Surgeon, Division of Gastrointestinal & Oncologic Surgery, Mass General, Associate Professor of Surgery, Harvard Medical School
Recent Article
Likelihood of Death at Home Is Improving in Colorectal Cancer, but Sociodemographic Disparities Persist
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Hiroko Kunitake, MD, MPH
Gastrointestinal and Colorectal Surgeon, Surgical Director, Perioperative Optimization of Senior Health (POSH) Clinic, Massachusetts General Hospital, Assistant Professor of Surgery, Harvard Medical School
Recent Article
New Multidisciplinary Clinic Aims to Improve Surgical Outcomes in Older Adults -
Liliana G. Bordeianou, MD, MPH, FACS, FASCRS
Site Director of the Colorectal Surgery Program, Co-Director, Pelvic Floor Disorders Center, Mass General, Co-Chair, Mass General Brigham Colorectal Surgery Collaborative, Professor of Surgery, Harvard Medical School
Recent Article
New Scoring System Allows Assessment of the Severity of Ileoanal Pouch Syndrome
Mass General Cancer Center
An integral part of one of the world’s most distinguished academic medical centers, the Massachusetts General Hospital Cancer Center is among the leading cancer care providers in the United States.
