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Featured
New Targeted Glioma Therapy Could Suppress Tumor Growth
Mass General has developed a genotype-targeted therapy for glioma, designed to be given at the tumor site during surgery, and an accompanying rapid diagnostic.
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Featured
Surviving Gliomas Through Antibodies and Vaccination
Immunotherapy for glioma is under active investigation, but tumor-associated immunosuppression is a major obstacle. A Mass General team studied an investigational monoclonal antibody in mice with glioma, alone and in combination with tumor cell vaccination.
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Featured
How Liquid Biopsy Could Improve Brain Tumor Treatment and Diagnoses
Mass General doctors are developing a liquid biopsy for brain tumors to reduce the need for invasive tissue biopsies.
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Review: The Role of Antibody-Based Therapies in Neuro-Oncology
Rishab Ramapriyan, William T. Curry, MD, Bryan D. Choi, MD, PhD, and colleagues describe the antibody-based therapies being used to treat glioblastoma and other central nervous system tumors, with special attention to the challenges of blood–brain barrier penetration and tumor-derived immunosuppression.
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Rare IDH2-mutant Glioma Shares Common Molecular Targets With IDH1-mutant Glioma
Massachusetts General Hospital researchers provide evidence that gene alterations that activate the retinoblastoma and PDGFR pathways have a pivotal biological role in the progression of IDH2-mutant astrocytoma, which is equivalent to progressive IDH1-mutated glioma, and they identified potential drug targets.
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Review: Oncolytic Herpes Simplex Viruses for Treatment of Glioma
Kimia Kardani, PhD, Judit Sánchez Gil, PhD, and Samuel D. Rabkin, PhD, describe in a review how herpes simplex viruses can be engineered to treat cancer safely, and they discuss the current state of oncolytic virus therapy for glioblastoma.
Brain Tumor Contributors
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Bob S. Carter, MD, PhD
Chief, Neurosurgery Service
Recent Article
Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease -
Brian V. Nahed, MD, MSc
Neurosurgical Oncology / Brain Tumor Surgeon / Mass General Brain Tumor Center, Neurosurgical Spinal Disorders, Associate Professor, Harvard Medical School
Director, Mass General Neurosurgery Residency ProgramRecent Article
Cadaver-free Simulation Model Feasible for Improving Residents' Craniotomy Skills -
Daniel P. Cahill, MD, PhD
Neurosurgeon, Massachusetts General Hospital, Neurosurgical Oncologist, Mass General Cancer Center
Recent Article
Rare IDH2-mutant Glioma Shares Common Molecular Targets With IDH1-mutant Glioma -
William T. Curry, MD
Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology, Massachusetts General Hospital, Adeline Rose Wydotis Professor of Neurosurgery, Harvard Medical School
Recent Article
Review: The Role of Antibody-Based Therapies in Neuro-Oncology